FAHD1 and EXOSC4

Number of citations of the paper that reports this interaction (PubMedID 15231747)
57

Data Source:
BioGRID (two hybrid)

		FAHD1	EXOSC4
Description		fumarylacetoacetate hydrolase domain containing 1	exosome component 4
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intracellular Membrane-bounded Organelle
	Molecular Function	Oxaloacetate Decarboxylase Activity Acetylpyruvate Hydrolase Activity Fumarylpyruvate Hydrolase Activity Metal Ion Binding Acylpyruvate Hydrolase Activity	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process		Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Citric acid cycle (TCA cycle)	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		4 interacting genes: BNIP2 EXOSC4 PAXIP1 PLPP1	32 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HNRNPD LNX1 LRRC8D MPZL1 MTREX NEK1 PALS2 POLE2 PPARA PTEN SDCBP SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		81889	54512
HPRD ID		13286	16221
Ensembl ID		ENSG00000180185	ENSG00000178896
Uniprot IDs		Q6P587	Q9NPD3
PDB IDs		1SAW 6FOG 6FOH	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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