SHCBP1L and BRAP

Number of citations of the paper that reports this interaction (PubMedID 25820252)
5

Data Source:
BioGRID (two hybrid)

		SHCBP1L	BRAP
Description		SHC binding and spindle associated 1 like	BRCA1 associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Meiotic Spindle	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Binding	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Male Meiosis Cytokinesis Spermatogenesis Cell Differentiation Positive Regulation Of Chromosome Organization	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination
Pathways			RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		LDL cholesterol levels in HIV infection ( 33109212) Morning person ( 30696823)	Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence ( 31591379) Alcohol dependence symptom count ( 29460428) Alcohol use disorder (consumption score) ( 30940813) Asthma ( 30929738 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 29875488) Body mass index ( 26426971 25673413) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Coffee consumption ( 29367735) Colorectal cancer ( 26151821) Crohn's disease ( 28067908) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 21372407) Epilepsy ( 33913524) Esophageal cancer ( 19698717) Fish consumption ( 32895509) Gastroesophageal reflux disease ( 31527586) Hematological and biochemical traits ( 20139978) hemolysis of donated blood (osmotic) ( 34014839) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908) LDL cholesterol ( 24097068 20686565) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 30226566) Parental lifespan ( 30642433) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25854761 28537254) Response to alcohol consumption (flushing response) ( 29460428) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum folate levels ( 29953918) Serum uric acid levels ( 29124443) Small vessel stroke (CCSp classification) ( 32047268) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tea consumption ( 33080986) Tumor necrosis factor levels ( 32805626) Waist-to-hip ratio adjusted for BMI ( 34054925 34021172) Weight ( 34054925)
Interacting Genes		2 interacting genes: BRAP ZNF835	43 interacting genes: AKAP3 APOA1 ATMIN BRCA1 BRK1 CCDC105 CCDC30 CDC14A CENPF CNKSR1 DDB1 DNMT1 FAM184A FBXO2 HMG20A HRAS KSR1 LINC00852 NUMA1 PHLPP1 PTPN11 RBM12 SH2B3 SHCBP1L SKP2 SMARCE1 SYNE2 TANC2 TEX35 TRIM41 TRIM55 TRIM8 UBB UBC UBE2D2 UBE2H UBE2L3 USP15 USP4 YJU2 ZNF382 ZNF479 ZNF521
Entrez ID		81626	8315
HPRD ID		16634	05405
Ensembl ID		ENSG00000157060	ENSG00000089234
Uniprot IDs		Q9BZQ2	Q59H81 Q7Z569
PDB IDs
Enriched GO Terms of Interacting Partners?
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