TRIM11 and USP14

Number of citations of the paper that reports this interaction (PubMedID 29581427)
15

Data Source:
BioGRID (pull down, affinity chromatography technology, pull down)

		TRIM11	USP14
Description		tripartite motif containing 11	ubiquitin specific peptidase 14
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Proteasome Complex Nucleus Cytosol Plasma Membrane Cell Surface Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Endopeptidase Inhibitor Activity Protein Binding Proteasome Binding
	Biological Process	Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Viral Transcription Innate Immune Response Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Negative Regulation Of Neurogenesis Defense Response To Virus Negative Regulation Of Viral Release From Host Cell	Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Chemotaxis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Hip circumference (psychosocial stress interaction) ( 25271088) Non-Richardson's syndrome vs Richardson's syndrome in progressive supranuclear palsy ( 30066433)
Interacting Genes		9 interacting genes: MCL1 MED15 OGT PAX6 RNF126 TRIM27 TRIM29 TRIM35 USP14	12 interacting genes: ATF2 CXCR4 FANCC OGT SEM1 SPAG5-AS1 TRIM11 UBC USP15 USP21 USP28 XRCC6
Entrez ID		81559	9097
HPRD ID		07429	06279
Ensembl ID		ENSG00000154370	ENSG00000101557
Uniprot IDs		Q96F44	P54578
PDB IDs			2AYN 2AYO 5GJQ 6IIK 6IIL 6IIM 6IIN 6LVS
Enriched GO Terms of Interacting Partners?
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