CAMK4 and CAMKK2

Number of citations of the paper that reports this interaction (PubMedID 9822657)
78

Data Source:
HPRD (in vitro)

		CAMK4	CAMKK2
Description		calcium/calmodulin dependent protein kinase IV	calcium/calmodulin dependent protein kinase kinase 2
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse	Nucleoplasm Cytosol Neuron Projection
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Adaptive Immune Response Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Signal Transduction Long-term Memory Peptidyl-serine Phosphorylation Regulation Of T Cell Differentiation In Thymus Intracellular Signal Transduction Myeloid Dendritic Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation	MAPK Cascade Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Cellular Response To Reactive Oxygen Species Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation CAMKK-AMPK Signaling Cascade Positive Regulation Of Autophagy Of Mitochondrion
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Transcriptional activation of mitochondrial biogenesis CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Negative regulation of NMDA receptor-mediated neuronal transmission	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs
Drugs		K-00546 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one	Fostamatinib
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 31959851 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Blood pressure ( 17903302) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Motor coordination ( 34177493) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569) Type 1 diabetes ( 34012112)	Left ventricular obstructive tract defect (inherited effect) ( 28468790) Type 2 diabetes ( 29358691)
Interacting Genes		11 interacting genes: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 NUDT12 RELA	7 interacting genes: APP CALM1 CAMK1 CAMK4 CEP63 NEDD4 PRKACA
Entrez ID		814	10645
HPRD ID		07169	06467
Ensembl ID		ENSG00000152495	ENSG00000110931
Uniprot IDs		Q16566	A0A024RBP6 A0A024RBP8 A0A024RBQ0 A0A024RBQ3 Q96RR4
PDB IDs		2W4O	2ZV2 5UY6 5UYJ 5VT1 5YV8 5YV9 5YVA 5YVB 5YVC 6BKU 6BLE 6BQL 6BQP 6BQQ 6BRC 6CMJ 6EF5 6EWW 6FEL 6Y3O 6Y4K 6Y6B 6Y8A
Enriched GO Terms of Interacting Partners?
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