NPRL3 and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		NPRL3	APPBP2
Description		NPR3 like, GATOR1 complex subunit	amyloid beta precursor protein binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane GATOR1 Complex	Nucleus Nucleoplasm Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	GTPase Activator Activity Protein Binding	Microtubule Motor Activity Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Ventricular Septum Development Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Aorta Morphogenesis TORC1 Signaling Cardiac Muscle Tissue Development Regulation Of Catalytic Activity Roof Of Mouth Development Regulation Of Autophagosome Assembly	Intracellular Protein Transport Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Intracellular Transport
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Cardiometabolic and hematological traits ( 27668658) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 28453575 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23446634 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Serum metabolite levels ( 33031748) Sickle cell anemia (haemolysis) ( 23406172)	Interleukin-6 levels ( 33517400) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Waist-hip ratio ( 28552196)
Interacting Genes		3 interacting genes: APPBP2 FHL3 SESN3	120 interacting genes: - AADAC ACTN1 AHCY AIM2 AK3 ALDH1L1 ANKRD10 APP AR ARMCX5 ATP13A1 BCL7A BIN2 C1orf50 C6orf226 CALM3 CCDC167 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CST2 CTC1 CYBA DCD DHRS2 DHX16 DOLK DPEP1 DPYS EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GPRC5C GSTP1 H2AC15 HGFAC HIPK4 HSD3B7 HSPA4 ITGB4 ITGB5 KHK KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MAN2B2 MCOLN1 MFSD3 MGAT4B MLLT3 MMP28 MSH2 MSLN MUL1 MYLK NFYA NPRL3 PCSK5 PI4KAP2 PNPLA5 PPIL6 PPP1R8 PRKAA2 PRKACB PSAP PTCH1 PYROXD2 RAB7B RASSF5 RHEB RILPL1 RNF128 RNF34 RNGTT RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SLC7A10 SLC9A3R1 SNX5 SPDYE2 SPDYE2B ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 TNP2 TRMT2A UBE2R2 UGGT2 WAS WDR24 WFIKKN1 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		8131	10513
HPRD ID		11866	05616
Ensembl ID		ENSG00000103148	ENSG00000062725
Uniprot IDs		B7Z220 B7Z6Q0 Q12980 Q9BTE2	A0A024QZ47 Q92624
PDB IDs		6CES 6CET
Enriched GO Terms of Interacting Partners?
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