CALR and HLA-C

Number of citations of the paper that reports this interaction (PubMedID 8769474)
149

Data Source:
HPRD (in vivo)

		CALR	HLA-C
Description		calreticulin	major histocompatibility complex, class I, C
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Membrane Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Cortical Granule Collagen-containing Extracellular Matrix Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Complement Component C1q Complex Binding DNA Binding RNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Folding Chaperone Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding	Protein Binding Peptide Antigen Binding TAP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Spermatogenesis Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein Maturation By Protein Folding Ubiquitin-dependent ERAD Pathway Cortical Actin Cytoskeleton Organization Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum Regulation Of Meiotic Nuclear Division Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Regulation Of Cell Cycle Cardiac Muscle Cell Differentiation Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Dendritic Cell Chemotaxis	Adaptive Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Innate Immune Response
Pathways		ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Antihemophilic factor, human recombinant Tenecteplase Melatonin Lanoteplase Copper Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Platelet count ( 32888494) Red blood cell traits ( 23222517)	AIDS progression ( 19115949) Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Asthma ( 27182965 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 23042114 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 33549134) Basophil count ( 32888494) Beta-2 microglubulin plasma levels ( 23417110) Birth weight ( 31043758) Blood cell traits (multivariate analysis) ( 31080455) Blood protein levels ( 29875488 28240269) Body shape index ( 34021172) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cervical cancer ( 28806749) Chickenpox ( 28928442) Childhood ear infection ( 27182965 28928442) Cholesterol, total ( 26582766) Chronic hepatitis B infection ( 25802187) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Cold sores ( 28928442) Complement C3 and C4 levels ( 23028341) Coronary heart disease ( 22319020) Crohn's disease ( 23128233 26891255) Cutaneous psoriasis ( 26626624) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Drug-induced liver injury (flucloxacillin) ( 30661239) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31015462) Feeling hurt ( 29500382) Feeling nervous ( 29500382) Feeling worry ( 29500382) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25282103 23563607 31562340) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatitis B ( 24162738) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) HIV-1 control ( 21051598 20041166) HIV-1 susceptibility ( 23935489) HIV-1 viral setpoint ( 26039976) Hypothyroidism ( 22493691) IgE levels ( 24324648) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 28067908) Irritable bowel syndrome ( 33608531) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol ( 26582766) Leprosy ( 32421744) Leukoderma in response to rhododendrol ( 32558222) Lung cancer ( 28604730) Lymphocyte counts ( 32888494 27863252) Major depressive disorder and major depressive episode treated with electroconvulsive therapy ( 33483693) Major depressive episode treated with electroconvulsive therapy ( 33483693) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mean platelet volume ( 32888494) Monocyte count ( 29403010) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Myositis ( 26291516) Nasopharyngeal carcinoma ( 20512145) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 29403010 32888494 27863252) Nevirapine-induced hypersensitivity in HIV (Stevens-Johnson syndrome or toxic epidermal necrosis) ( 28062682) Non-albumin protein levels ( 29403010) Offspring birth weight ( 31043758) Perceived unattractiveness to mosquitoes ( 28199695) Plantar warts ( 28928442) Pneumonia ( 28928442) Protein quantitative trait loci ( 18464913) Psoriasis ( 30921485 20953188 20953190 23143594 18369459 18364390 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 20953186) Red blood cell count ( 32888494) Response to hepatitis B vaccine ( 29534301) Reticulocyte count ( 27863252) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Self-reported allergy ( 23817569) Serum albumin level ( 29403010) Setpoint viral load in HIV-1 infection ( 26553974) Severity of facial solar lentigines ( 27327535) Shingles ( 28928442) Small cell lung carcinoma ( 28604730) Squamous cell lung carcinoma ( 28604730) Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) ( 21912425) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Takayasu arteritis ( 25604533) Tonsillectomy ( 27182965 28928442) Triglyceride levels ( 33339817) Tuberculosis ( 28928442) Type 1 diabetes (age at diagnosis) ( 33179336) Ulcerative colitis ( 28067908) Vitiligo ( 20526339) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count ( 29403010 32888494 27863252 21738480 28158719) White blood cell count (basophil) ( 29403010) White blood cell count (lymphocyte) ( 28158719)
Interacting Genes		54 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB GSC2 HLA-A HLA-C HLA-E ICAM1 ICAM3 ITGA2B ITGA3 ITGAV ITIH1 LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 OGT PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SGTB SIRPA SLC2A1 SLC6A4 SMARCB1 SQSTM1 SUMO4 TAF1B TAPBP TF THBS1 TRIM21 TSHR UBE3A UPF2 VWF	24 interacting genes: B2M BATF2 CALR CD8A CDC25A GPR182 GPR37 HSPA5 KIR2DL1 KIR2DL2 KIR2DL3 KIR2DS1 KIR2DS2 KIR2DS4 LILRB1 LILRB2 MAPK8IP2 NPSR1 OPRL1 PRRG4 TANK TAP2 TAPBP YBX1
Entrez ID		811	3107
HPRD ID		00169	00829
Ensembl ID		ENSG00000179218	ENSG00000204525
Uniprot IDs		P27797 V9HW88	O19617 P10321 Q6R739 Q95HC2
PDB IDs		2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY	1EFX 1IM9 1QQD 3BZF 4NT6 5VGD 5VGE 5W67 5W69 5W6A 6JTO 6PA1 6PAG
Enriched GO Terms of Interacting Partners?
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