NDFIP1 and UQCRH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NDFIP1	UQCRH
Description		Nedd4 family interacting protein 1	ubiquinol-cytochrome c reductase hinge protein
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Endoplasmic Reticulum Golgi Apparatus Cell Cortex Endosome Membrane Integral Component Of Membrane Dendrite Synapse Perinuclear Region Of Cytoplasm	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respirasome Mitochondrial Respiratory Chain Complex III
	Molecular Function	Protein Binding WW Domain Binding	Protein Binding Ubiquinol-cytochrome-c Reductase Activity
	Biological Process	Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of Type 2 Immune Response Ubiquitin-dependent Protein Catabolic Process Cellular Iron Ion Homeostasis Vacuolar Transport Negative Regulation Of Gene Expression Metal Ion Transport Positive Regulation Of Protein Ubiquitination Negative Regulation Of Transporter Activity Negative Regulation Of Interleukin-4 Production Negative Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lymphocyte Differentiation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Inflammatory Response Negative Regulation Of Protein Transport	Oxidative Phosphorylation Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Aerobic Respiration Proton Transmembrane Transport
Pathways			Respiratory electron transport
Drugs			2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474 29273806 22561531) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte count ( 27863252) HDL levels x SSRI levels (escitalopram or citalopram) interaction in schizophrenia or bipolar disorder ( 33824429) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Low susceptibility to hepatitis C infection ( 31206233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Physiological traits ( 31902109) Platelet count ( 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494)	Body mass index ( 26426971) Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: BDKRB1 CCR2 ITCH NEDD4 NTRK2 PTEN SMO UQCRH WWP2	7 interacting genes: ARL8A FAM189B NDFIP1 NDFIP2 NPM1 PRRG1 RNF24
Entrez ID		80762	7388
HPRD ID		14816	15629
Ensembl ID		ENSG00000131507	ENSG00000173660
Uniprot IDs		Q9BT67	P07919 Q567R0
PDB IDs			5XTE 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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