CCDC92 and TP53BP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CCDC92	TP53BP2
Description		coiled-coil domain containing 92	tumor protein p53 binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Centriole Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Identical Protein Binding	P53 Binding Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding
	Biological Process		Cell Cycle Signal Transduction Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Neuron Death
Pathways			Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Body shape index ( 34021172) Coronary artery disease ( 29212778 28714974) Hand grip strength ( 29691431) HDL cholesterol ( 20686565) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 31453325) Hip circumference adjusted for BMI ( 34021172) Hip circumference variance ( 31453325) Hip index ( 34021172) Lymphocyte counts ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549) Triglycerides ( 20686565) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172) Waist circumference variance ( 31453325) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971 30389748) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count ( 32888494 27863252)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Triptolide cytotoxicity ( 26121980)
Interacting Genes		15 interacting genes: CEP76 CHGB COG6 DISC1 FHL2 FXR1 FXR2 GOLGA2 PLEKHA5 PSMD8 TCTN2 TP53BP2 TRIM27 TRIML2 UBC	124 interacting genes: ADAMTS12 APP APPL1 ARHGEF6 ATPAF2 ATXN7 AXIN1 BAG3 BAIAP2 BCAS2 BCL2 BCL2L1 CCDC13 CCDC57 CCDC85A CCDC92 CDC5L CEP55 CEP95 CGN CREBBP CRK CSNK2B CWF19L2 DCUN1D1 DDX6 DIRAS1 DISC1 EEF1A1 EFHC1 ELOA GCC1 GEM GFAP GOLGA1 GPS2 GRB2 H2BC4 H2BC9 HHEX HIF1AN HNRNPUL1 HSF2BP HYOU1 INSYN2A IQUB KDM1A KIF5A LHX4 LMNB1 LMNB2 LMO4 MAGI1 MAPK8IP2 MOS MRPL20 MTMR14 MTURN NAE1 NEDD4 NFKB1 NHSL2 NUTM1 OTUB2 PHF1 PIBF1 PLEKHF2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CB PPP1CC PRAM1 PRKAB2 PRPF31 PTN RALBP1 RASAL3 RASSF10 RASSF8 RELA RGMA RXRB SCNM1 SETD5 SH3KBP1 SH3RF1 SHTN1 SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TROAP TSGA10 TXLNA TYK2 UBASH3A UBASH3B UBE3A UBTD1 UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YOD1 YWHAG YWHAQ ZBTB4 ZFP91 ZGPAT ZNF26 ZNF438 ZNF552 ZNF575
Entrez ID		80212	7159
HPRD ID		16919	11803
Ensembl ID		ENSG00000119242	ENSG00000143514
Uniprot IDs		Q53HC0	Q13625
PDB IDs			1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?
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