C3orf36 and MAP2K5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		C3orf36	MAP2K5
Description		chromosome 3 putative open reading frame 36	mitogen-activated protein kinase kinase 5
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Spindle Cytosol
	Molecular Function	Protein Binding	Protein Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Signal Transduction Heart Development Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Growth Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Negative Regulation Of Response To Cytokine Stimulus ERK5 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Signalling to ERK5
Drugs			Fostamatinib
Diseases
GWAS			Adult body size ( 32376654) Asthma ( 31959851) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28552196 22344219 26961502 24861553 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Dental caries (decayed and filled deciduous teeth) ( 31533690) Menarche (age at onset) ( 25231870) Motion sickness ( 25628336) Obesity ( 23563607) Proportion of activated microglia (midfrontal cortex) ( 30679421) Restless legs syndrome ( 17637780 33239738 29029846 21779176) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969 32499647) Verbal declarative memory ( 25648963) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		23 interacting genes: ANKS1A APP BANP HDAC7 HGS MAP2K5 NRF1 PIK3R3 PIN1 PPP1R16A PPP2CA PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E RIPPLY2 TENT5B TRIM55 TRIM63 UBTFL1 ZNF76	57 interacting genes: AKT1 ARAF ARNT ASRGL1 BAD BBS2 BECN1 C3orf36 CCND2 CD44 CDC42BPB CDK4 CDK6 CDKN2A CDKN2B CDKN2C DUSP21 EPHA2 ERBB2 ESRRA FGFR4 FZR1 GLIS2 GRM1 GUCD1 HGF HIF1A LATS2 LNX2 MAP2K3 MAP2K6 MAP3K2 MAP3K3 MAPK7 MDM4 MET MYC NF2 NMB PARD6A PDGFRA PFDN5 PRKCI PRKCZ RAF1 RPL28 SQSTM1 STAMBP STK11 TEAD2 TERT TP53 TSC1 XRCC6 YWHAZ ZNF426 ZNF620
Entrez ID		80111	5607
HPRD ID		07981	03951
Ensembl ID		ENSG00000288547	ENSG00000137764
Uniprot IDs			A0A024R5X5 A0A024R5Y2 Q13163
PDB IDs			2NPT 2O2V 4IC7
Enriched GO Terms of Interacting Partners?
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