DHDDS and NPC2

Number of citations of the paper that reports this interaction (PubMedID 15110773)
6

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		DHDDS	NPC2
Description		dehydrodolichyl diphosphate synthase subunit	NPC intracellular cholesterol transporter 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Dehydrodolichyl Diphosphate Synthase Complex	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome
	Molecular Function	Polyprenyltransferase Activity Protein Binding Dehydrodolichyl Diphosphate Synthase Activity Metal Ion Binding	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity
	Biological Process	Dolichyl Diphosphate Biosynthetic Process Polyprenol Biosynthetic Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport Intermembrane Lipid Transfer
Pathways		Synthesis of Dolichyl-phosphate Defective DHDDS causes retinitis pigmentosa 59	Neutrophil degranulation LDL clearance
Drugs
Diseases
GWAS		Caffeine consumption from tea ( 33287642) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Serum alkaline phosphatase levels ( 33339817)	Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: LOX MT-ND1 NPC2 VRK2	19 interacting genes: AREL1 BARD1 BRCA1 CTSW DHDDS ECT2 EIF2B2 EOLA1 ERRFI1 LIG4 PAXIP1 PDIA6 SCNN1A SCRN1 SSR1 TMED10 TRIM14 USP4 VASH1
Entrez ID		79947	10577
HPRD ID		12183	03008
Ensembl ID		ENSG00000117682	ENSG00000119655
Uniprot IDs		Q86SQ9	A0A024R6C0 P61916
PDB IDs		6W2L 6Z1N	5KWY 6W5V
Enriched GO Terms of Interacting Partners?
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