SPEF2 and TSC22D2

Number of citations of the paper that reports this interaction (PubMedID 27337956)
22

Data Source:
BioGRID (two hybrid)

		SPEF2	TSC22D2
Description		sperm flagellar 2	TSC22 domain family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Manchette Extracellular Region Cytoplasm Golgi Apparatus Sperm Flagellum Sperm Midpiece
	Molecular Function	Molecular_function
	Biological Process	Epithelial Cilium Movement Involved In Extracellular Fluid Movement Spermatogenesis Sperm Axoneme Assembly Skeletal System Morphogenesis Brain Morphogenesis Respiratory System Development	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress
Pathways
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma or allergic disease (pleiotropy) ( 29785011) Hemoglobin levels ( 33491795) Homeostasis model assessment of insulin resistance ( 33381925) Periventricular white matter hyperintensities ( 32517579) Primary biliary cirrhosis ( 22961000) Pulse pressure x educational attainment (some college) interaction (2df) ( 32372009) Response to lurasidone in schizophrenia ( 29730043)	Adiponectin levels ( 22479202) Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cortical surface area (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29235454) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Moyamoya disease ( 29273593) PR interval ( 32439900) Pulse pressure ( 27841878) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30054458 30297969) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: MTDH TSC22D2	42 interacting genes: ANAPC10 ANKRD36 ARID2 ATP1B1 CCDC141 CCDC144A CLIP1 DNAAF11 ENOPH1 EPCAM F8 FLNB GPBP1 ITGA2 KIAA0586 LOXHD1 LPL MED13 MPDZ MSH3 MTIF2 NGRN OSBPL1A PRMT3 PSMA7 PSMA8 RBL1 REV1 RNF2 SAP18 SCEL SEC31A SNX3 SPEF2 STK39 TMA7 TTN UFM1 WNK3 ZMYM2 ZNF143 ZNF251
Entrez ID		79925	9819
HPRD ID		11181	11101
Ensembl ID		ENSG00000152582	ENSG00000196428
Uniprot IDs		A0A140VKD0 Q9C093	B4DN36 O75157
PDB IDs
Enriched GO Terms of Interacting Partners?
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