NHEJ1 and XRCC4

Number of citations of the paper that reports this interaction (PubMedID 17567543)
32

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		NHEJ1	XRCC4
Description		non-homologous end joining factor 1	X-ray repair cross complementing 4
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex	Condensed Chromosome Nucleus Nucleoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Site Of Double-strand Break Nonhomologous End Joining Complex
	Molecular Function	Protein Binding DNA End Binding DNA Polymerase Binding	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity Identical Protein Binding FHA Domain Binding
	Biological Process	Double-strand Break Repair Via Nonhomologous End Joining Central Nervous System Development Response To Ionizing Radiation B Cell Differentiation T Cell Differentiation Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Protein Localization To Site Of Double-strand Break
Pathways		Nonhomologous End-Joining (NHEJ)	2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)
Drugs			S-(Dimethylarsenic)Cysteine
Diseases
GWAS		Height ( 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Serum polyunsaturated fatty acid concentration x sex interaction in metabolic syndrome ( 31991592) Thyroid stimulating hormone levels ( 32769997) Waist circumference adjusted for body mass index ( 34021172)	Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		2 interacting genes: LIG4 XRCC4	24 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GSC2 GZMB HAUS2 IFFO1 KRT27 LIG4 MAGEA6 NBN NHEJ1 OGT PNKP PRKDC VIM
Entrez ID		79840	7518
HPRD ID		07784	15951
Ensembl ID		ENSG00000187736	ENSG00000152422
Uniprot IDs		Q9H9Q4	A0A024RAL0 A0A024RAP0 A0A024RAQ8 Q13426 Q7Z763
PDB IDs		2QM4 2R9A 3Q4F 3RWR 3SR2 3W03 6ERG 6ERH	1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO
Enriched GO Terms of Interacting Partners?
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