GSDMD and ZNF558

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		GSDMD	ZNF558
Description		gasdermin D	zinc finger protein 558
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytosol Plasma Membrane Integral Component Of Membrane Specific Granule Lumen NLRP3 Inflammasome Complex Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Cellular_component Nucleus
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidic Acid Binding Cardiolipin Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding
	Biological Process	Inflammatory Response Cellular Response To Extracellular Stimulus Positive Regulation Of Interleukin-1 Beta Production Pore Formation In Membrane Of Other Organism Defense Response To Bacterium Innate Immune Response Pore Complex Assembly Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Protein Homooligomerization Pyroptosis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Biological_process
Pathways		Release of apoptotic factors from the mitochondria Interleukin-1 processing Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Purinergic signaling in leishmaniasis infection	Generic Transcription Pathway
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Monocyte count ( 32888494) Schizophrenia ( 31268507)
Interacting Genes		8 interacting genes: ASPG KCTD6 MEOX2 MFHAS1 PSMA1 ZBTB33 ZNF426 ZNF558	12 interacting genes: APOE CLK2 CSNK2A1 EFEMP2 EIF1AD EXOSC5 GSDMD HEXIM2 LZIC MAD2L2 MFAP1 UBTFL1
Entrez ID		79792	148156
HPRD ID		11014	15841
Ensembl ID		ENSG00000104518	ENSG00000167785
Uniprot IDs		P57764	Q96NG5
PDB IDs		5NH1 5WQT 6AO4 6KN0 6N9O
Enriched GO Terms of Interacting Partners?
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