MCPH1 and SUPT6H

Number of citations of the paper that reports this interaction (PubMedID 29150431)
8

Data Source:
BioGRID (two hybrid)

		MCPH1	SUPT6H
Description		microcephalin 1	SPT6 homolog, histone chaperone and transcription elongation factor
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Organizing Center	Nucleoplasm Transcription Elongation Factor Complex Transcriptionally Active Chromatin
	Molecular Function	Protein Binding Identical Protein Binding	DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance	Blastocyst Formation Transcription Elongation From RNA Polymerase II Promoter MRNA Processing RNA Splicing Regulation Of MRNA Export From Nucleus Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Nucleosome Organization MRNA Transcription By RNA Polymerase II Regulation Of Isotype Switching Regulation Of MRNA Processing MRNA Transport Regulation Of Muscle Cell Differentiation Negative Regulation Of Histone H3-K27 Methylation
Pathways		Condensation of Prophase Chromosomes	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)	Pulse pressure ( 30578418)
Interacting Genes		68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2	13 interacting genes: AKT1 CSNK2A1 DNAJB6 EGFR ERBB2 ERCC6 GAB1 HSP90B1 HSPA9 HSPD1 IWS1 MCPH1 TSC2
Entrez ID		79648	6830
HPRD ID		06174	03211
Ensembl ID		ENSG00000147316	ENSG00000109111
Uniprot IDs		Q8NEM0	Q7KZ85
PDB IDs		2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D	6GME 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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