DERL1 and FCRL4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DERL1	FCRL4
Description		derlin 1	Fc receptor like 4
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Protease Binding Signal Recognition Particle Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding Protein-containing Complex Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Response To Unfolded Protein Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization ER-associated Misfolded Protein Catabolic Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway
Pathways		ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)	Blood protein levels ( 29875488)
Interacting Genes		32 interacting genes: ABHD4 AMFR APP AQP6 CFTR CIAO2A FCRL4 FFAR2 GAD2 HLA-A KASH5 LMNA LNX1 MELTF REEP4 RETREG3 RHO SCN3B SELENOS SLC10A1 SLC10A6 SLC30A8 SLC7A14 SLC7A8 TCF25 TEX44 TMED8 TMEM31 TMX2 TRIM32 UBXN6 VCP	10 interacting genes: BMP10 DERL1 DTX2 FCRL5 JAGN1 NINJ2 S100A16 TFF1 TFF2 ZNF76
Entrez ID		79139	83417
HPRD ID		12302	16168
Ensembl ID		ENSG00000136986	ENSG00000163518
Uniprot IDs		A0A024R9G3 E5RGY0 Q9BUN8	Q96PJ5
PDB IDs		5GLF
Enriched GO Terms of Interacting Partners?
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