DEK and TFAP2A

Number of citations of the paper that reports this interaction (PubMedID 12595566)
40

Data Source:
HPRD (in vitro, in vivo)

		DEK	TFAP2A
Description		DEK proto-oncogene	transcription factor AP-2 alpha
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Contractile Fiber	Chromatin Nucleus Nucleoplasm
	Molecular Function	DNA Binding RNA Binding Protein Binding Histone Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding Nuclear Receptor Corepressor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Signal Transduction Viral Genome Replication Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Trigeminal Nerve Development Oculomotor Nerve Formation Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Roof Of Mouth Development Bone Morphogenesis Eyelid Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Metabolite levels ( 23823483) PR interval ( 32439900)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Breast cancer in BRCA2 mutation carriers ( 23544012) Glucose homeostasis traits ( 25524916) Iron status biomarkers (ferritin levels) ( 28334935) Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Zinc levels ( 26025379)
Interacting Genes		17 interacting genes: AP2A1 CDC42 CREBBP CSNK2A1 DTNBP1 EP300 GPATCH11 H3-4 HLA-A KAT2B OGT PCSK5 SRRM1 TFAP2A TRIM55 TRIM63 ZIK1	38 interacting genes: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CSNK2A1 CSNK2B CTNNB1 DEK EP300 EPN1 EPN2 EPS15 GSTO2 HIP1 INCA1 KCTD15 LDLRAP1 MAGI1 MKRN3 MYC NFKB1 NPM1 PPARG PRKAA2 PRKD1 RB1 SRA1 SUMO4 SYT1 TP53 UBE2I VEGFA WWP1 WWP2 YBX1
Entrez ID		7913	7020
HPRD ID		00503	00128
Ensembl ID		ENSG00000124795	ENSG00000137203
Uniprot IDs		H0Y993 P35659	P05549
PDB IDs		1Q1V 2JX3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?