OTUB2 and PMEPA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		OTUB2	PMEPA1
Description		OTU deubiquitinase, ubiquitin aldehyde binding 2	prostate transmembrane protein, androgen induced 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Golgi Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Thiol-dependent Deubiquitinase Protein Binding Ubiquitin Binding	Protein Binding WW Domain Binding R-SMAD Binding
	Biological Process	Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair	Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Pathways		Ovarian tumor domain proteases	Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster) ( 33455090) Response to tofacitinib treatment in rheumatoid arthritis (herpes zoster)(time to event) ( 33455090) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		42 interacting genes: APP ARRDC3 CDIP1 CPSF6 DAZAP2 FAM168A GLI2 KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 MKRN1 PHLDA2 PJA1 PLEKHB2 PMEPA1 RBCK1 REL RFFL RNF126 SIAH1 SPART TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 U2AF2 UBC UBE2N USP21 USP28	11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4
Entrez ID		78990	56937
HPRD ID		07620	09415
Ensembl ID		ENSG00000089723	ENSG00000124225
Uniprot IDs		Q96DC9	Q5JY37 Q969W9
PDB IDs		1TFF 4FJV 5QIO 5QIP 5QIQ 5QIR 5QIS 5QIT 5QIU 5QIV 5QIW 5QIX 5QIY 5QIZ
Enriched GO Terms of Interacting Partners?
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