CRELD1 and EIF6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CRELD1	EIF6
Description		cysteine rich with EGF like domains 1	eukaryotic translation initiation factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane Collagen-containing Extracellular Matrix	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Endocardial Cushion Development Cardiac Septum Development	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs			Copper
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HOXA1 HTR2C KAT5 MAP3K1 MTNR1B NUFIP2 POLA2 PTN SETDB1 SHANK3 ZNF408	41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26
Entrez ID		78987	3692
HPRD ID		06206	04221
Ensembl ID		ENSG00000163703	ENSG00000242372
Uniprot IDs		A0A024R2G1 Q96HD1	P56537
PDB IDs			6LQM 6LSR 6LSS 6LU8
Enriched GO Terms of Interacting Partners?
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