USP7 and PHLDB2

Number of citations of the paper that reports this interaction (PubMedID 26496610)
430

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		USP7	PHLDB2
Description		ubiquitin specific peptidase 7	pleckstrin homology like domain family B member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body PML Body Protein-containing Complex	Cytosol Plasma Membrane Focal Adhesion Cell Leading Edge Intermediate Filament Cytoskeleton Basal Cortex
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activity Lys48-specific Deubiquitinase Activity	Protein Binding Cadherin Binding
	Biological Process	Regulation Of Gluconeogenesis Transcription-coupled Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Maintenance Of DNA Methylation Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Telomere Capping Regulation Of Retrograde Transport, Endosome To Golgi	Microtubule Cytoskeleton Organization Regulation Of Gastrulation Regulation Of Epithelial To Mesenchymal Transition Establishment Of Protein Localization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization
Drugs
Diseases
GWAS		Chronotype ( 30696823) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Atrial fibrillation ( 30061737 29892015) Cognitive performance ( 20125193) Crohn's disease-related phenotypes ( 25557950) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) PR interval ( 30046033 32439900)
Interacting Genes		106 interacting genes: ABRAXAS2 ACD ANKS1A ANXA1 ARNT2 ATXN1 AXIN1 BCOR BEND5 CBX8 CLSPN CREB3L3 CRY1 CSNK2A1 DAXX DCTPP1 DNAJA3 DNMT3A ECT2 ERCC6 EWSR1 FANCD2 FOXN2 GATA1 H2AC20 H2BC3 H2BU1 H3C1 HECW1 HERPUD1 HIF1A HTRA2 HUWE1 IFNAR1 KLHL8 LINC02582 MAGEE1 MAL MARCHF7 MCMBP MDM2 MDM4 MYC MYD88 NECAB2 NEDD4L NOTCH1 OTUD4 PCGF2 PEG3 PEPD PHF8 PHLDB2 PICK1 PKM PLA2G2A PLEKHO1 PLK1 PPARG PPL PSMD4 PTEN RAD18 RADIL RARA RB1 RBCK1 RELA RFFL RNF168 RNF220 SMAD3 SNCA SUMO2 SYVN1 TANK TBCB TFIP11 TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBA52 UBC UBE2D3 UBE2E1 UBE2S USP21 USP28 VCP WWP2 XPC ZMYND8 ZNF423 ZNF76	5 interacting genes: CLK1 FLNC USP7 YWHAG YWHAQ
Entrez ID		7874	90102
HPRD ID		03950	06611
Ensembl ID		ENSG00000187555	ENSG00000144824
Uniprot IDs		B7Z855 B7ZAX6 Q6U8A4 Q93009	Q86SQ0
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H 6P5L 6VN2 6VN3 6VN4 6VN5 6VN6 7CM2
Enriched GO Terms of Interacting Partners?
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