IL1R2 and IL1RN

Number of citations of the paper that reports this interaction (PubMedID 1834644)
11

Data Source:
HPRD (in vivo)

		IL1R2	IL1RN
Description		interleukin 1 receptor type 2	interleukin 1 receptor antagonist
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Space Cytoplasm Plasma Membrane Extracellular Exosome
	Molecular Function	Interleukin-1 Receptor Activity Interleukin-1, Type II, Blocking Receptor Activity Protein Binding Interleukin-1 Binding	Cytokine Activity Interleukin-1, Type I Receptor Binding Interleukin-1, Type II Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding Interleukin-1 Type I Receptor Antagonist Activity Interleukin-1 Type II Receptor Antagonist Activity
	Biological Process	Immune Response Negative Regulation Of Protein Processing Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-1 Alpha Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Interleukin-1-mediated Signaling Pathway	Inflammatory Response To Antigenic Stimulus Lipid Metabolic Process Inflammatory Response Immune Response Signal Transduction Insulin Secretion Negative Regulation Of Heterotypic Cell-cell Adhesion Response To Glucocorticoid Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Interleukin-10 signaling Interleukin-1 signaling	Interleukin-10 signaling Interleukin-1 signaling
Drugs			Rilonacept
Diseases
GWAS		Ankylosing spondylitis ( 23749187 20062062) Asthma ( 31619474) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576 29875488) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Inflammatory bowel disease ( 28067908 23128233) Parkinson's disease ( 32201043 28892059) Ulcerative colitis ( 21297633)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576 29875488) C-reactive protein ( 22939635) C-reactive protein levels ( 33339817) Dysmenorrheic pain ( 27454463) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Granulocyte count ( 27863252) Interleukin-6 levels ( 33517400) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301) Stroke ( 26089329) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252)
Interacting Genes		5 interacting genes: IL1A IL1B IL1RAP IL1RN USP15	6 interacting genes: COPS3 COPS4 IL1R1 IL1R2 POT1 TERF2IP
Entrez ID		7850	3557
HPRD ID		00995	00978
Ensembl ID		ENSG00000115590	ENSG00000136689
Uniprot IDs		P27930	A0A024R528 P18510
PDB IDs		3O4O	1ILR 1ILT 1IRA 1IRP 1ITN 2IRT
Enriched GO Terms of Interacting Partners?
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