ZP3 and SPACA3

Number of citations of the paper that reports this interaction (PubMedID 19945174)
11

Data Source:
BioGRID (two hybrid)

		ZP3	SPACA3
Description		zona pellucida glycoprotein 3	sperm acrosome associated 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix Egg Coat Collagen-containing Extracellular Matrix	Acrosomal Vesicle Acrosomal Membrane Extracellular Region Integral Component Of Membrane Secretory Granule Sperm Flagellum Acrosomal Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity	Lysozyme Activity Protein Binding
	Biological Process	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Signal Transduction Binding Of Sperm To Zona Pellucida Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth	Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Sperm-egg Recognition Monocyte Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Phagocytosis
Pathways		Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		Parkinson disease and lewy body pathology ( 25663231)	Plasma anti-thyroid peroxidase levels ( 29678681) Red cell distribution width ( 32888494) Refractive error ( 32231278) Thyroxine levels ( 30843173)
Interacting Genes		11 interacting genes: ACR CLDN11 ENGASE FURIN MALL MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L	1 interacting genes: ZP3
Entrez ID		7784	124912
HPRD ID		01690	15420
Ensembl ID		ENSG00000188372	ENSG00000141316
Uniprot IDs		P21754	A0A080YUZ7 E9PF91 Q05C28 Q8IXA5
PDB IDs
Enriched GO Terms of Interacting Partners?
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