CA9 and CDH1

Number of citations of the paper that reports this interaction (PubMedID 14567991)
74

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		CA9	CDH1
Description		carbonic anhydrase 9	cadherin 1
Image
GO Annotations	Cellular Component	Nucleolus Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane Microvillus Membrane	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Actin Cytoskeleton Integral Component Of Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity	Calcium Ion Binding Protein Binding Beta-catenin Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Response To Hypoxia Morphogenesis Of An Epithelium One-carbon Metabolic Process Response To Xenobiotic Stimulus Response To Testosterone Secretion	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Synapse Assembly Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Cell Migration Neuron Projection Development Adherens Junction Organization Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription, DNA-templated Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Pathways		Regulation of gene expression by Hypoxia-inducible Factor Reversible hydration of carbon dioxide	Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells
Drugs		Benzthiazide Benzthiazide Cyclothiazide Hydroflumethiazide Zonisamide Girentuximab Ellagic acid Sodium carbonate
Diseases
GWAS			Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 32341527 26237428) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Nevus count or cutaneous melanoma ( 32341527) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Ulcerative colitis ( 19915572)
Interacting Genes		7 interacting genes: CAND1 CDH1 CDKN2A CSRP1 CTNNA1 CTNNB1 GLRX3	69 interacting genes: ACTR3 AKT1 ANAPC7 AOPEP ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC42 CDH5 CDK8 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBIN EZR FER FGFR1 FYN GALNT12 GNA12 GNA13 GSK3B HDAC1 HDAC2 HEMGN HRAS HSD17B3 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MAP2K1 MAPK3 MSANTD3 MYO6 NANS NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SFRP2 SKP2 STOML2 STX17 TMOD1 UCA1 UCHL3 VCL YES1 ZNF510
Entrez ID		768	999
HPRD ID		04417	01885
Ensembl ID		ENSG00000107159	ENSG00000039068
Uniprot IDs		A0A0S2Z3D0 Q16790	A0A0U2ZQU7 B3GN61 P12830 Q9UII7
PDB IDs		2HKF 3IAI 5DVX 5FL4 5FL5 5FL6 6FE0 6FE1 6FE2 6G98 6G9U 6QN2 6QN5 6QN6 6QUT 6RQN 6RQQ 6RQU 6RQW 6TL5 6TL6 6Y74	1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG 6VEL
Enriched GO Terms of Interacting Partners?
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