PTTG1IP and TMEM106C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PTTG1IP	TMEM106C
Description		PTTG1 interacting protein	transmembrane protein 106C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Integral Component Of Membrane Extracellular Exosome	Cellular_component Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	P53 Binding Molecular_function Protein Binding	Molecular_function Protein Binding
	Biological Process	Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cellular Protein Catabolic Process	Biological_process
Pathways
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Apolipoprotein A1 levels ( 32203549) Delirium ( 29631748) Gamma glutamyl transferase levels ( 29403010) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 28957414)	Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: AIRE AMIGO1 ATP6AP2 CLEC7A LDLRAD1 PTTG1 RAB4A RUNX1 SGCB SLC22A23 TMEM106C TMPRSS2 TNFSF14	42 interacting genes: ADAM33 AIG1 BNIP3 C14orf180 CLDN19 CMTM7 CTXN3 CXCL9 EDDM3B FAXDC2 GOSR2 HACD1 IGFBP5 JAGN1 KRT31 KRTAP10-3 MAL MARCHF2 MYADM NKG7 NRSN1 PGA4 PLN PLP1 PLPP6 PTTG1IP RPRM SEC22A SERP2 SFTPC SMAGP TMEM106A TMEM106B TMEM11 TMEM218 TMEM35A TMEM97 TSPAN33 UPK2 VAMP5 YIPF6 ZFPL1
Entrez ID		754	79022
HPRD ID		04807	14690
Ensembl ID		ENSG00000183255	ENSG00000134291
Uniprot IDs		B4DPZ0 P53801	Q9BVX2
PDB IDs
Enriched GO Terms of Interacting Partners?
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