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ZFP36 and YWHAH
Number of citations of the paper that reports this interaction (PubMedID
11886850
)
54
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
ZFP36
YWHAH
Description
ZFP36 ring finger protein
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Image
GO Annotations
Cellular Component
P-body
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
Ribonucleoprotein Complex
Cytoplasm
Cytosol
Plasma Membrane
Intercalated Disc
Extracellular Exosome
Molecular Function
DNA Binding
RNA Binding
MRNA Binding
Protein Binding
Enzyme Binding
Protein Kinase Binding
C-C Chemokine Binding
Heat Shock Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Protein-containing Complex Binding
Metal Ion Binding
RNA Polymerase Binding
14-3-3 Protein Binding
Actin Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Sodium Channel Regulator Activity
Enzyme Binding
Protein Domain Specific Binding
Glucocorticoid Receptor Binding
Identical Protein Binding
Transmembrane Transporter Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Poly(A) Tail Shortening
MRNA Catabolic Process
Response To Wounding
Regulation Of Keratinocyte Proliferation
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay
Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Viral Transcription
MiRNA Mediated Inhibition Of Translation
P38MAPK Cascade
Response To Starvation
Regulation Of MRNA Stability
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Fat Cell Differentiation
Regulation Of Keratinocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Negative Regulation Of Inflammatory Response
MRNA Transport
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
3'-UTR-mediated MRNA Destabilization
3'-UTR-mediated MRNA Stabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Regulation Of Keratinocyte Apoptotic Process
Negative Regulation Of Polynucleotide Adenylyltransferase Activity
Positive Regulation Of Intracellular MRNA Localization
Positive Regulation Of Gene Silencing By MiRNA
Regulation Of Sodium Ion Transport
Glucocorticoid Catabolic Process
Intracellular Protein Transport
Signal Transduction
Substantia Nigra Development
Cellular Protein Localization
Glucocorticoid Receptor Signaling Pathway
Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Regulation Of Synaptic Plasticity
Negative Regulation Of Dendrite Morphogenesis
Membrane Depolarization During Action Potential
Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Post bronchodilator FEV1 (
26634245
)
Type 2 diabetes (
30297969
)
Interacting Genes
28 interacting genes:
APP
ATG16L1
CCDC85B
CDK6
CXCL8
DCP1B
DHX36
DNAJB1
EDC3
EXOSC6
EXOSC8
FHL3
HMGB1
HOXC9
MAPK1
MAPKAPK2
MX1
NCL
NUP214
RUNX1T1
SFN
TNF
UPF2
XRN1
YWHAB
YWHAG
YWHAH
ZDHHC17
66 interacting genes:
ABL1
ARHGEF28
BAD
BCR
BRAF
CCDC125
CDC25B
CDC25C
CDC42
CDK16
CDKN1B
CHRNA4
CREBBP
EPB41L2
EPB41L3
ESR1
ESR2
EXO1
GREM1
HSPB1
ING1
KANK1
KCNH2
KCNK15
KCNK3
KCNK9
KIF5B
KLC3
KRT18
MAP3K3
MAP3K5
MARK4
MDM4
MED1
MST1R
NCOA1
NCOA2
NCOA3
NEK1
NHSL2
NR3C1
NRIP1
PARD3
PARD6A
PARD6B
PDPK1
PRKCI
PRKN
PTH1R
RAF1
REM1
RIMS1
RIMS2
RPH3A
SAMSN1
SNCA
SRC
THRA
TLX2
TNFAIP3
TPH1
TSC1
TSC2
YWHAE
YWHAG
ZFP36
Entrez ID
7538
7533
HPRD ID
01835
00215
Ensembl ID
ENSG00000128016
ENSG00000128245
Uniprot IDs
M0QY76
P26651
A0A024R1K7
Q04917
Q9H4N8
PDB IDs
4J8S
2C63
2C74
Enriched GO Terms of Interacting Partners
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