YWHAB and HSPA1B

Number of citations of the paper that reports this interaction (PubMedID 15324660)
184

Data Source:
HPRD (in vivo)

		YWHAB	HSPA1B
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta	heat shock protein family A (Hsp70) member 1B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Vacuolar Membrane Cytosol Focal Adhesion Membrane Transcription Repressor Complex Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Plasma Membrane Focal Adhesion Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Deacetylase Binding Protein-containing Complex Binding Cadherin Binding Phosphoserine Residue Binding Phosphoprotein Binding	Virus Receptor Activity G Protein-coupled Receptor Binding RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Histone Deacetylase Binding Protein Folding Chaperone Protein N-terminus Binding Unfolded Protein Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Protein Disaggregase Activity
	Biological Process	Protein Targeting Signal Transduction Cellular Protein Localization Negative Regulation Of Protein Dephosphorylation Positive Regulation Of Catalytic Activity Negative Regulation Of Catalytic Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cytoplasmic Sequestering Of Protein	MRNA Catabolic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Regulation Of Cell Death Vesicle-mediated Transport Negative Regulation Of Cell Growth Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Viral Entry Into Host Cell Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Cell Death Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Regulation Of Mitotic Spindle Assembly Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane MTOR signalling mTORC1-mediated signalling Frs2-mediated activation Frs2-mediated activation ARMS-mediated activation Signaling by Hippo Rap1 signalling Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA RHO GTPases activate PKNs TP53 Regulates Metabolic Genes RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors Signaling downstream of RAS mutants Signaling by RAF1 mutants SHOC2 M1731 mutant abolishes MRAS complex function Gain-of-function MRAS complexes activate RAF signaling	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation
Drugs		Copper Phenethyl Isothiocyanate
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Breakfast cereal skipping frequency ( 31190057) Breakfast skipping ( 31190057) Mean platelet volume ( 32888494)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Eosinophilic esophagitis ( 29904099) Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 32771030) Ulcerative colitis ( 28067908)
Interacting Genes		143 interacting genes: ABL1 ADAM22 AFDN AKAP13 ALS2 APP ATP5F1A BAD BAX BCL2L11 BCR BID BRAF C1QBP CAMK2A CAMK2B CBL CDC25A CDC25B CDC25C CDK11B CDK14 CDKN1B CHAF1A CRTC2 CSNK2A1 DAPK1 DCAF7 DHX15 DYRK1A EDC3 EGFR EPB41 EPB41L1 EPB41L3 ERRFI1 EXO1 FER FRMD6 GAPVD1 GEM H3C1 HDAC5 HES1 HSP90AB1 HSPA1A HSPA1B HSPA5 HSPB1 IGF1R IKBKB ING1 INSR IRS1 IRS2 ITGB1 ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIAA0930 KIF1C KIF23 KIF5B KLC1 KRT18 LARP1 LYST MAP3K3 MAPK7 MAPT MARK2 MARK4 MDM4 MICALL1 MINK1 MLXIP MPRIP MST1R MTNR1A MTNR1B OSBPL3 PARD3 PARD6B PDCL2 PDE3B PI4KB PIK3R2 PIK3R4 PRKCD PRKCG PRKCZ PRPF6 PTPN3 RABGEF1 RACGAP1 RADIL RAF1 RAI14 RALGPS2 RASGRF1 RGS3 RGS7 RIN1 RIOK1 RMDN3 RNPS1 RPS6KA1 SAMSN1 SKP2 SLC4A7 SLC8A1 SLC8A2 SLC8A3 SLC9A1 SNCA SNRNP200 SON SRC SRRM2 SRSF10 SRSF3 STK38 STK38L TESK1 TESK2 TH TJP2 TNFAIP3 TPD52L1 TSC1 TSC2 TUBB UBC UCP2 UCP3 WDR77 WEE1 YWHAE YWHAG ZFP36 ZFP36L1	21 interacting genes: AIFM1 BAG1 BAG4 BNIP2 DNMBP F2RL1 FAF1 HSPBP1 MYBPC2 PGAM5 SGCG ST13 STIP1 STUB1 SUMO4 TGM2 TOMM70 TRIM38 TTN YWHAB YWHAZ
Entrez ID		7529	3304
HPRD ID		03184	06784
Ensembl ID		ENSG00000166913	ENSG00000204388
Uniprot IDs		P31946 V9HWD6	A8K5I0 P0DMV8 P0DMV9
PDB IDs		2BQ0 2C23 4DNK 5N10 6A5Q 6BYK 6GN0 6GN8 6GNJ 6GNK 6GNN 6HEP	1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39
Enriched GO Terms of Interacting Partners?
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