XRCC3 and GREB1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
8

Data Source:
BioGRID (two hybrid)

		XRCC3	GREB1
Description		X-ray repair cross complementing 3	growth regulating estrogen receptor binding 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Mitochondrion Cytosol Rad51C-XRCC3 Complex Perinuclear Region Of Cytoplasm	Nucleoplasm Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Four-way Junction DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Crossover Junction Endodeoxyribonuclease Activity
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Response To Organic Substance Regulation Of Centrosome Duplication Interstrand Cross-link Repair Double-strand Break Repair Via Synthesis-dependent Strand Annealing Resolution Of Mitotic Recombination Intermediates Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint T-circle Formation Telomeric Loop Disassembly Telomere Maintenance Via Telomere Trimming	Multicellular Organism Development
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange	Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971 29273807) Schizophrenia ( 25056061 29483656)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diisocyanate-induced asthma ( 25918132) Endometriosis ( 23104006 28537267) Gynecologic disease (multivariate analysis) ( 31488892) High density lipoprotein cholesterol levels ( 30108155) Inferior parietal cortex volume ( 31530798) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Uterine fibroids ( 30194396 31649266)
Interacting Genes		22 interacting genes: BAP1 BCAS3 CXCL1 FANCG GREB1 ITIH5 LRATD2 MRC2 OSGIN1 PALB2 PSMC3IP RAD51 RAD51C RAD51D RNF20 SCGB3A1 SERPINB5 SNAI1 SWSAP1 TFF1 ZNHIT3 ZSWIM7	11 interacting genes: BCAR3 CASP8 CDKN2C HMMR HRAS LSP1 PALB2 RB1CC1 SMAD4 TGFB1 XRCC3
Entrez ID		7517	9687
HPRD ID		07201	13611
Ensembl ID		ENSG00000126215	ENSG00000196208
Uniprot IDs		O43542 Q53XC8	Q4ZG55
PDB IDs
Enriched GO Terms of Interacting Partners?
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