NSD2 and SLBP

		NSD2	SLBP
Description		nuclear receptor binding SET domain protein 2	stem-loop binding protein
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex
	Molecular Function	Chromatin Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	RNA Binding MRNA Binding Protein Binding Identical Protein Binding Histone Pre-mRNA Stem-loop Binding Histone Pre-mRNA DCP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Transport
Pathways		PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Hip minimal joint space width ( 27701424) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)
Interacting Genes		17 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H3-4 H3C14 HORMAD2 MDC1 NELFA NOP14 PCNA PLEKHF2 SH3BP2 SLBP SMURF1	10 interacting genes: CDK4 CDK6 DCAF11 ERI1 FBN1 LSM10 NSD2 PTGER4 USP8 ZNF473
Entrez ID		7468	7884
HPRD ID		04259	03884
Ensembl ID		ENSG00000109685	ENSG00000163950
Uniprot IDs		O96028	B3KSC5 B3KST9 B4DUW7 E7EUV9 Q14493 Q53XR2
PDB IDs		5LSU 5VC8 6UE6 6XCG 7CRO	2KJM 4L8R 4QOZ
Enriched GO Terms of Interacting Partners?
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