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VHL and KLF4
Number of citations of the paper that reports this interaction (PubMedID
22284679
)
38
Data Source:
BioGRID
(affinity chromatography technology, pull down)
VHL
KLF4
Description
von Hippel-Lindau tumor suppressor
Kruppel like factor 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Membrane
Chromatin
Euchromatin
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Ubiquitin Ligase-substrate Adaptor Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Phosphatidylinositol 3-kinase Regulator Activity
Histone Deacetylase Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Regulation Of Transcription, DNA-templated
Proteolysis
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT
Protein Stabilization
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Transcription By RNA Polymerase II
Defense Response To Tumor Cell
Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Mesodermal Cell Fate Determination
Negative Regulation Of Cell Population Proliferation
Epidermal Cell Differentiation
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Muscle Hyperplasia
Negative Regulation Of Angiogenesis
Stem Cell Population Maintenance
Post-embryonic Camera-type Eye Development
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Interleukin-8 Production
Negative Regulation Of Heterotypic Cell-cell Adhesion
Post-embryonic Hemopoiesis
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Nitric Oxide Biosynthetic Process
Fat Cell Differentiation
Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Hemoglobin Biosynthetic Process
Negative Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Axon Regeneration
Epidermis Morphogenesis
Negative Regulation Of Inflammatory Response
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Telomerase Activity
Canonical Wnt Signaling Pathway
Negative Regulation Of Response To Cytokine Stimulus
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Growth Factor Stimulus
Cellular Response To Cycloheximide
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Blastocyst Development
Cellular Response To Peptide
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Core Promoter Binding
Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Cellular Response To Leukemia Inhibitory Factor
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SUMOylation of ubiquitinylation proteins
Neddylation
Replication of the SARS-CoV-1 genome
Replication of the SARS-CoV-2 genome
RHOBTB3 ATPase cycle
Antigen processing: Ubiquitination & Proteasome degradation
Transcriptional regulation of white adipocyte differentiation
Synthesis, secretion, and deacylation of Ghrelin
Transcriptional regulation of pluripotent stem cells
FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS
Bullous pemphigoid (
34011352
)
Hip circumference adjusted for BMI (
34021172
)
Breast cancer (
21263130
)
Colorectal or endometrial cancer (
26621817
)
Coronary artery disease (
33020668
)
Cotinine glucuronidation (
25293881
)
Cutaneous malignant melanoma (
26237428
)
Glycated hemoglobin levels (
34059833
28898252
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Heel bone mineral density (
30598549
28869591
)
Myocardial infarction (
33532862
)
Prostate cancer (
23023329
)
Psoriasis (
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Takayasu arteritis (
25604533
)
Tenofovir clearance in HIV infection (
26148204
)
Interacting Genes
109 interacting genes:
ACTB
AKT1
APP
AURKA
CAPN7
CAPZB
CASR
CBR1
CBX1
CBX3
CCNC
CCT3
CD44
CDC34
CDKN2A
CERKL
CHEK2
CLU
COL4A2
CSNK2A1
CUL2
CUL5
DGKI
DNAJA3
DVL2
E2F1
EEF1B2
EGLN1
ELOB
ELOC
EPAS1
EPOR
FKBP8
FLNA
FN1
GHET1
GPS1
H1-2
H2BC13
H4-16
HDAC1
HDAC2
HDAC3
HIF1A
HIF1AN
HIF3A
HNRNPA2B1
HNRNPD
HSF2BP
HSPA5
HSPA8
IKBKB
JADE1
KIF2C
KIF3A
KLF4
LANCL1
MAP1LC3B
MDFI
NCL
NR4A1
NR4A2
NR4A3
OTUD6B
PDCD5
PIAS4
PLD1
PLD2
POLR2G
PPP5C
PRDX1
PRKCI
PRMT1
PRMT8
PSMC3
RB1CC1
RBPMS
RBPMS2
RBX1
RHOBTB3
RNF139
RPL21
RPL5
RPS15A
RWDD3
SARNP
SAT2
SKP2
SLC2A1
SLC3A2
SON
SP1
TPT1
TRIM28
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2S
USP20
USP33
USP9X
UXT
VAPB
VBP1
WSB1
YY1AP1
ZNF197
ZNF512B
22 interacting genes:
APP
CREBBP
DVL3
ELK1
EP300
FBXO7
GYS1
HDAC1
HDAC5
HGS
HSF2BP
KAT5
KLF6
MYO15B
PAX9
PLK1
SETD7
SP1
TLE5
TP53
USP10
VHL
Entrez ID
7428
9314
HPRD ID
01905
03769
Ensembl ID
ENSG00000134086
ENSG00000136826
Uniprot IDs
A0A024R2F2
A0A0S2Z4K1
P40337
O43474
PDB IDs
1LM8
1LQB
1VCB
3ZRC
3ZRF
3ZTC
3ZTD
3ZUN
4AJY
4AWJ
4B95
4B9K
4BKS
4BKT
4W9C
4W9D
4W9E
4W9F
4W9G
4W9H
4W9I
4W9J
4W9K
4W9L
4WQO
5LLI
5N4W
5NVV
5NVW
5NVX
5NVY
5NVZ
5NW0
5NW1
5NW2
5T35
6BVB
6FMI
6FMJ
6FMK
6GFX
6GFY
6GFZ
6GMN
6GMQ
6GMR
6GMX
6HAX
6HAY
6HR2
6I7Q
6I7R
6R6H
6R7F
6SIS
6ZHC
7KHH
Enriched GO Terms of Interacting Partners
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