VASP and PFN1

Number of citations of the paper that reports this interaction (PubMedID 10882740)
68

Data Source:
HPRD (in vitro)

		VASP	PFN1
Description		vasodilator stimulated phosphoprotein	profilin 1
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Membrane Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding	Adenyl-nucleotide Exchange Factor Activity Phosphotyrosine Residue Binding RNA Binding Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Small GTPase Binding Cadherin Binding Proline-rich Region Binding
	Biological Process	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization	Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Regulation Of Catalytic Activity Protein Stabilization Negative Regulation Of Stress Fiber Assembly Synapse Maturation Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Ruffle Assembly
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions	Platelet degranulation Signaling by ROBO receptors PCP/CE pathway RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs			7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARIN Artenimol
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)	Mean platelet volume ( 32888494)
Interacting Genes		44 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP CDC42 CEP43 DMRTB1 DNMBP ENAH ERMAP EVL FAT1 FRS3 FYB1 GSN IQGAP1 LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX	33 interacting genes: ACTA1 ACTB AFDN APBB1IP CMA1 CRMP1 DBN1 DLG5 DNM2 ENAH ERG28 FMNL1 GPHN LRIF1 MYPOP NCK1 PIK3R1 RAD51 RHOQ SIRPA SRPK1 STUB1 TLE1 TRAF6 TRIM15 UNC119 VASP VIPR1 WASF1 WASL WIPF2 XPO6 YWHAQ
Entrez ID		7408	5216
HPRD ID		03415	01452
Ensembl ID		ENSG00000125753	ENSG00000108518
Uniprot IDs		A0A024R0V4 P50552	P07737
PDB IDs		1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW	1AWI 1CF0 1CJF 1FIK 1FIL 1PFL 2PAV 2PBD 3CHW 4X1L 4X1M 4X25 6NAS 6NBE 6NBW
Enriched GO Terms of Interacting Partners?
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