KDM6A and MAGED2

		KDM6A	MAGED2
Description		lysine demethylase 6A	MAGE family member D2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytosol Membrane Platelet Alpha Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3-tri/di-methyl-lysine-27 Demethylase Activity	Protein Binding
	Biological Process	Chromatin Remodeling Heart Development Regulation Of Gene Expression Histone H3-K4 Methylation Histone H3-K27 Demethylation	Negative Regulation Of Transcription By RNA Polymerase II Female Pregnancy Renal Sodium Ion Absorption
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis	Platelet degranulation
Drugs
Diseases
GWAS
Interacting Genes		19 interacting genes: AKAP4 BMP15 CREBBP ELK1 GSC2 H3-4 H3C1 H3C14 HSD17B10 MAGED2 MEOX2 MTDH NKX2-5 RBM3 SMAD9 SRF TBX5 TLE1 ZNF157	4 interacting genes: CHRM3 EEF1A1 KDM6A PTEN
Entrez ID		7403	10916
HPRD ID		02131	06630
Ensembl ID		ENSG00000147050	ENSG00000102316
Uniprot IDs		A0A087X0R0 A0A6Q8PFK0 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3 Q86TD1	A0A024R9Y7 Q9UNF1
PDB IDs		3AVR 3AVS 6FUK 6FUL
Enriched GO Terms of Interacting Partners?
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