UCP2 and VEGFB

		UCP2	VEGFB
Description		uncoupling protein 2	vascular endothelial growth factor B
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Membrane Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Oxidative Phosphorylation Uncoupler Activity	Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Chemoattractant Activity Identical Protein Binding Vascular Endothelial Growth Factor Receptor 1 Binding
	Biological Process	Response To Superoxide Response To Hypoxia Female Pregnancy Aging Response To Cold Positive Regulation Of Cell Death Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Negative Regulation Of Apoptotic Process Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Fatty Acid Cellular Response To Glucose Stimulus Liver Regeneration Positive Regulation Of Cold-induced Thermogenesis Proton Transmembrane Transport Mitochondrial Transmembrane Transport Adaptive Thermogenesis	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Sprouting Angiogenesis Protein O-linked Glycosylation Response To Xenobiotic Stimulus Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cell Division Cardiac Muscle Contraction Positive Regulation Of Mast Cell Chemotaxis Coronary Vasculature Development
Pathways		The fatty acid cycling model The proton buffering model	Platelet degranulation VEGF ligand-receptor interactions VEGF binds to VEGFR leading to receptor dimerization
Drugs			Aflibercept
Diseases
GWAS		Mean platelet volume ( 32888494)	Apolipoprotein A1 levels ( 32203549) Body shape index ( 34021172) Crohn's disease ( 28067908) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Fruit consumption ( 32066663) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Red blood cell count ( 32888494) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		7 interacting genes: KRTAP10-3 KRTAP10-7 VEGFB YWHAB YWHAG YWHAQ YWHAZ	11 interacting genes: ADRB2 FLT1 FOSL1 KLHL12 NRP1 SF1 TFB1M TNXB UCP2 UCP3 VEGFA
Entrez ID		7351	7423
HPRD ID		03410	03237
Ensembl ID		ENSG00000175567	ENSG00000173511
Uniprot IDs		A0A024R5N5 P55851	P49765 Q7LAP4
PDB IDs			2C7W 2VWE 2XAC
Enriched GO Terms of Interacting Partners?
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