UCN and CRHR2

Number of citations of the paper that reports this interaction (PubMedID 11416224)
231

Data Source:
HPRD (in vivo, in vitro)

		UCN	CRHR2
Description		urocortin	corticotropin releasing hormone receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Dendrite Varicosity Perikaryon Axon Terminus	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Axon Terminus
	Molecular Function	Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding	Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity
	Biological Process	Startle Response Inflammatory Response Response To Oxidative Stress G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Associative Learning Aerobic Respiration Negative Regulation Of Gene Expression Response To Auditory Stimulus Pancreatic Juice Secretion Positive Regulation Of Cell Growth Negative Regulation Of Histone Deacetylation Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Activation Of Protein Kinase A Activity Social Behavior Gastric Emptying Vasodilation Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of CAMP-mediated Signaling Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Necrotic Cell Death Positive Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response	Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways		Class B/2 (Secretin family receptors) Synthesis, secretion, and deacylation of Ghrelin	G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Crohn's disease ( 23128233)	Type 2 diabetes ( 24509480 30297969)
Interacting Genes		5 interacting genes: CRHBP CRHR1 CRHR2 LEP RAB18	8 interacting genes: APP CRH GCC1 GPR35 MALL UCN UCN2 UCN3
Entrez ID		7349	1395
HPRD ID		02970	03614
Ensembl ID		ENSG00000163794	ENSG00000106113
Uniprot IDs		P55089	A0A090N7T4 Q13324
PDB IDs		2RMF 3N96 6PB0 6PB1	3N93 3N95 3N96 6PB1
Enriched GO Terms of Interacting Partners?
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