UBE2N and RNF135

Number of citations of the paper that reports this interaction (PubMedID 33373584)
7

Data Source:
BioGRID (pull down)

		UBE2N	RNF135
Description		ubiquitin conjugating enzyme E2 N	ring finger protein 135
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol UBC13-MMS2 Complex Protein-containing Complex UBC13-UEV1A Complex Extracellular Exosome	Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding RIG-I Binding Identical Protein Binding Ribonucleoprotein Complex Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Histone Ubiquitination Positive Regulation Of Histone Modification Regulation Of Histone Ubiquitination Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Repair T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Protein K63-linked Ubiquitination	Protein Polyubiquitination Free Ubiquitin Chain Polymerization Protein Ubiquitination Positive Regulation Of Interferon-beta Production RIG-I Signaling Pathway Innate Immune Response Regulation Of Innate Immune Response Protein Homooligomerization Protein K63-linked Ubiquitination Antiviral Innate Immune Response
Pathways		ISG15 antiviral mechanism NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Height ( 18391951) Mean reticulocyte volume ( 32888494)	Height ( 18391951) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		115 interacting genes: AMFR ARIH1 ARIH2 AURKA BARD1 BCL10 BFAR BIRC2 BIRC3 BIRC8 BRCA1 CADPS2 CBL CCNB1 CHFR CHUK CNOT4 DTL DTX1 DZIP3 F12 HERC2 HSP90AA1 LRSAM1 MALT1 MARCHF5 MARCHF7 MDM2 MIB1 MIB2 MID1 MKRN3 MUL1 MYLIP NBN NEDD4L NEURL1 NFX1 OTUB1 OTUB2 PEDS1 PEDS1-UBE2V1 PELI1 PELI3 PJA2 PRKN PTTG1 RBCK1 RC3H1 RC3H2 RFFL RFWD3 RIPK1 RNF103 RNF11 RNF111 RNF115 RNF122 RNF125 RNF126 RNF128 RNF13 RNF130 RNF135 RNF152 RNF165 RNF167 RNF181 RNF182 RNF38 RNF4 RNF43 RNF5 RNF8 SH3RF1 SH3RF2 SHPRH SIAH1 SIAH2 SLC2A4 STUB1 TNFAIP3 TOPORS TP53 TRAF2 TRAF6 TREX2 TRIM14 TRIM17 TRIM23 TRIM25 TRIM27 TRIM28 TRIM32 TRIM33 TRIM39 TRIM5 TRIM50 TRIM54 TRIM63 TRIM65 TRIM69 TRIM72 UBA1 UBB UBC UBE2V1 UBE2V2 UBE3A UHRF1 XIAP ZNRF1 ZNRF2 ZNRF3 ZNRF4	10 interacting genes: CTBP2 CTNNAL1 DDX58 ENOX2 GOLGA2 HSF2BP IFIH1 TEPSIN UBE2D2 UBE2N
Entrez ID		7334	84282
HPRD ID		04725	11506
Ensembl ID		ENSG00000177889	ENSG00000181481
Uniprot IDs		P61088 V9HW41	B3KV69 Q8IUD6
PDB IDs		1J7D 2C2V 3HCT 3HCU 3VON 3W31 4DHI 4DHJ 4DHZ 4IP3 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 4TKP 4WHV 5AIT 5AIU 5EYA 5H7S 5VNZ 5VO0 5YWR 6D6I 6JKY 6KFP 6KG6 6KL4 6LP2 6P5B 6S53 6ULH 6UMP 6UMS 7BBD 7BBF 7BXG	7JL1 7JL3
Enriched GO Terms of Interacting Partners?
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