UBE2D3 and UHRF1

Number of citations of the paper that reports this interaction (PubMedID 27595565)
44

Data Source:
BioGRID (pull down, x-ray crystallography)

		UBE2D3	UHRF1
Description		ubiquitin conjugating enzyme E2 D3	ubiquitin like with PHD and ring finger domains 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Nuclear Matrix
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Cis-regulatory Region Sequence-specific DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Nucleosomal Histone Binding Methylated Histone Binding Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination DNA Repair Cellular Protein Modification Process Protein Monoubiquitination Apoptotic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Cadmium Ion Cellular Response To Mercury Ion Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Maintenance Of DNA Methylation Histone Monoubiquitination Protein Ubiquitination Histone Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Protein Autoubiquitination Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation	DNA methylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma and attention deficit hyperactivity disorder ( 31619474) Diastolic blood pressure ( 30224653) Fasting glucose ( 33402679) Shoulder impingement or rotator cuff tear ( 33482370)	Age at first sexual intercourse ( 34211149) Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		212 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 ATXN3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CSNK2A1 CUL2 CUL4B DBN1 DCAF1 DCUN1D1 DDX58 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO7 FBXW11 FBXW8 FOCAD FZR1 HDAC6 HECTD1 HECW1 HECW2 HERC1 HERC2 HSP90AB1 HSPA1A HUWE1 IKBKG ITCH KAT2B KDM1B LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PJA1 PJA2 POLL POLM PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF213 RNF216 RNF220 RNF25 RNF26 RNF31 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SIAH1 SIAH2 SMURF1 SMURF2 SQSTM1 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TRAF6 TRAIP TRIM10 TRIM17 TRIM2 TRIM23 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA VHL WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNRF1 ZNRF2 ZNRF4	27 interacting genes: DNMT3A ERCC1 ERG FANCD2 FZR1 H2AC4 H2BC3 H3-3A H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 LASP1 LIG1 MBD4 MUS81 PCLAF PCNA PRKACA TP53 UBE2D1 UBE2D3 UBE2N UHRF2
Entrez ID		7323	29128
HPRD ID		04269	06992
Ensembl ID		ENSG00000109332	ENSG00000276043
Uniprot IDs		A0A024RDH2 D6RAH7 P61077	A0A087WVR3 Q96T88
PDB IDs		1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F 7JZV	2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED 6VYJ 6W92
Enriched GO Terms of Interacting Partners?
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