TXN and NCF4

Number of citations of the paper that reports this interaction (PubMedID 10397171)
7

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		TXN	NCF4
Description		thioredoxin	neutrophil cytosolic factor 4
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	RNA Binding Thioredoxin-disulfide Reductase Activity Protein Binding Protein-disulfide Reductase Activity Protein Homodimerization Activity Protein-disulfide Reductase (NAD(P)) Activity	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glycerol Ether Metabolic Process Response To Radiation Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of DNA Binding Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Kinase B Signaling Response To Nitric Oxide Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Peptidyl-cysteine S-nitrosylation	Phagocytosis Superoxide Anion Generation Respiratory Burst Regulation Of Catalytic Activity
Pathways		Oxidative Stress Induced Senescence Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes Protein repair The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle
Drugs		Phenethyl Isothiocyanate	Dextromethorphan
Diseases
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		38 interacting genes: ACTN1 ACTN4 ANKRD11 APEX1 CDKN1A COL1A1 COPS5 DDIT4L DNAJA1 DYNLT1 EGFR ERBB2 ERBB3 ERBB4 FST GFER GPRASP2 MAP3K5 MLH1 MRFAP1 MYD88 NCF4 NFE2 NFKB1 NIF3L1 NR3C1 NUP62 PTEN SERTAD3 SIAH1 SPG21 SRPK2 TEX13A TP53 TRAF2 TXNIP UCHL5 VIM	10 interacting genes: CORO1A CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6
Entrez ID		7295	4689
HPRD ID		01761	03289
Ensembl ID		ENSG00000136810	ENSG00000100365
Uniprot IDs		H9ZYJ2 P10599	A0A494BZS1 Q15080
PDB IDs		1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4LL1 4LL4 4OO4 4OO5 4POK 4POL 4POM 4PUF 4TRX 5DQY	1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?
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