TUBA4A and CXCR1

		TUBA4A	CXCR1
Description		tubulin alpha 4a	C-X-C motif chemokine receptor 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Kinase Binding	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle	Dendritic Cell Chemotaxis Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs		Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate	Ketoprofen
Diseases
GWAS		Platelet distribution width ( 32888494 27863252)	Basophil count ( 32888494) Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)
Interacting Genes		66 interacting genes: ALPP APC ARHGAP1 ATP5MC3 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 CAPN2 CDK5R2 CXCR1 DPYSL2 EGFR ENO2 EPB41 ETV6 FYN GNAI2 GPHN GRM7 HDAC6 HPCA HSPH1 IL1RL1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD NUPR1 OGT PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 SKP1 SLC11A1 STARD13 STK16 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UCHL5 VAV1 VDAC1 WNT6 YWHAG ZAP70	21 interacting genes: ADRA1A CDK1 CLDND1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 FATE1 GNA14 GNA15 GNAI2 IGFBP5 PDCD6IP PPBP TRARG1 TUBA1A TUBA4A UBE2C
Entrez ID		7277	3577
HPRD ID		01851	00908
Ensembl ID		ENSG00000127824	ENSG00000163464
Uniprot IDs		P68366	P25024
PDB IDs			1ILP 1ILQ 2LNL
Enriched GO Terms of Interacting Partners?
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