TTR and DDR1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		TTR	DDR1
Description		transthyretin	discoidin domain receptor tyrosine kinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Azurophil Granule Lumen Extracellular Exosome	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Hormone Activity Protein Binding Identical Protein Binding Thyroid Hormone Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Purine Nucleobase Metabolic Process Signal Transduction Retinol Metabolic Process Thyroid Hormone Transport	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Embryo Implantation Lactation Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Smooth Muscle Cell Migration Positive Regulation Of Kinase Activity Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion Axon Development Neuron Projection Extension
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Non-integrin membrane-ECM interactions Neutrophil degranulation Retinoid metabolism and transport Amyloid fiber formation	Non-integrin membrane-ECM interactions
Drugs		Zinc Copper Tafamidis Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Imatinib Fostamatinib Pralsetinib
Diseases
GWAS		Retinol levels ( 21878437)	Age-related macular degeneration ( 23455636) Arterial stiffness index ( 31235810) Autism spectrum disorder or schizophrenia ( 28540026) HIV-1 control ( 20041166) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Malaria ( 31844061) Microalbuminuria in type 1 diabetes ( 31537649) Response to hepatitis B vaccine ( 29534301) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking initiation (ever regular vs never regular) ( 30679032) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		49 interacting genes: A2M ACTB AGER APOA1 ATF4 ATF5 BAG6 CDR2 CEP126 CHD3 CLU CPNE6 CTNND2 DDR1 EEF1A1 ELP1 ERG28 FEZ1 GET3 GET4 HNRNPH3 HSP90AA1 HSPG2 INPP5K LRP2 MARK3 MT3 NDUFA5 NECAB2 NGFR OTUB1 PHYHIP PIK3R1 PRKCI QARS1 RAI1 RBP4 RNF115 SDF4 SETDB1 SP110 ST13 ST3GAL3 SUMO3 TAF1C TAF5L TUBA1A VIM ZBED1	20 interacting genes: BEND5 BRD2 COL11A1 COL2A1 COL3A1 COL5A2 ERBB2 FRS2 MAPK6 NCK2 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR UBQLN2
Entrez ID		7276	780
HPRD ID		01447	02678
Ensembl ID		ENSG00000118271	ENSG00000204580
Uniprot IDs		E9KL36 P02766	A0A024RCJ0 A0A024RCL1 A0A024RCQ1 A0A0A0MSX3 Q08345 Q96T61 Q96T62
PDB IDs		1BM7 1BMZ 1BZ8 1BZD 1BZE 1DVQ 1DVS 1DVT 1DVU 1DVX 1DVY 1DVZ 1E3F 1E4H 1E5A 1ETA 1ETB 1F41 1F64 1F86 1FH2 1FHN 1G1O 1GKO 1ICT 1III 1IIK 1IJN 1QAB 1QWH 1RLB 1SOK 1SOQ 1THA 1THC 1TLM 1TSH 1TT6 1TTA 1TTB 1TTC 1TTR 1TYR 1TZ8 1U21 1X7S 1X7T 1Y1D 1Z7J 1ZCR 1ZD6 2B14 2B15 2B16 2B77 2B9A 2F7I 2F8I 2FBR 2FLM 2G3X 2G3Z 2G4E 2G4G 2G5U 2G9K 2GAB 2H4E 2M5N 2NBO 2NBP 2NOY 2PAB 2QEL 2QGB 2QGC 2QGD 2QGE 2ROX 2ROY 2TRH 2TRY 2WQA 3A4D 3A4E 3A4F 3B56 3BSZ 3BT0 3CBR 3CFM 3CFN 3CFQ 3CFT 3CN0 3CN1 3CN2 3CN3 3CN4 3CXF 3D2T 3D7P 3DGD 3DID 3DJR 3DJS 3DJT 3DJZ 3DK0 3DK2 3DO4 3ESN 3ESO 3ESP 3FC8 3FCB 3GLZ 3GPS 3GRB 3GRG 3GS0 3GS4 3GS7 3HJ0 3I9A 3I9I 3I9P 3IMR 3IMS 3IMT 3IMU 3IMV 3IMW 3IPB 3IPE 3KGS 3KGT 3KGU 3M1O 3NEE 3NEO 3NES 3NEX 3NG5 3OZK 3OZL 3P3R 3P3S 3P3T 3P3U 3SSG 3TCT 3TFB 3U2I 3U2J 3W3B 4ABQ 4ABU 4ABV 4ABW 4AC2 4AC4 4ACT 4ANK 4D7B 4DER 4DES 4DET 4DEU 4DEW 4FI6 4FI7 4FI8 4HIQ 4HIS 4HJS 4HJT 4HJU 4I85 4I87 4I89 4IIZ 4IK6 4IK7 4IKI 4IKJ 4IKK 4IKL 4KY2 4L1S 4L1T 4MAS 4MRB 4MRC 4N85 4N86 4N87 4PM1 4PME 4PMF 4PVL 4PVM 4PVN 4PWE 4PWF 4PWG 4PWH 4PWI 4PWJ 4PWK 4QRF 4QXV 4QYA 4TKW 4TL4 4TL5 4TLK 4TLS 4TLT 4TLU 4TM9 4TNE 4TNF 4TNG 4TQ8 4TQH 4TQI 4TQP 4WNJ 4WNS 4WO0 4Y9B 4Y9C 4Y9E 4Y9F 4Y9G 4YDM 4YDN 5A6I 5AKS 5AKT 5AKV 5AL0 5AL8 5AYT 5BOJ 5CLX 5CLY 5CLZ 5CM1 5CN3 5CNH 5CR1 5DEJ 5DWP 5E23 5E4A 5E4O 5EN3 5EZP 5FO2 5FW6 5FW7 5FW8 5H0V 5H0W 5H0X 5H0Y 5H0Z 5HJG 5IHH 5JID 5JIM 5JIQ 5K1J 5K1N 5L4F 5L4I 5L4J 5L4M 5LLL 5LLV 5N5Q 5N62 5N7C 5NFE 5NFW 5OQ0 5TTR 5TZL 5U48 5U49 5U4A 5U4B 5U4C 5U4D 5U4E 5U4F 5U4G 6D0W 6E6Z 6E70 6E71 6E72 6E73 6E74 6E75 6E76 6E77 6E78 6EP1 6FFT 6FWD 6FXU 6FZL 6GR7 6GRP 6IMX 6IMY 6KGB 6R66 6R67 6R68 6R6I 6SDZ 6SUG 6SUH 6TI9 6TJN 6TXV 6TXW 6U0Q 6XTK 7ACU	3ZOS 4AG4 4BKJ 4CKR 5BVK 5BVN 5BVO 5BVW 5FDP 5FDX 6BRJ 6BSD 6FEW 6FEX 6FIL 6FIN 6FIO 6FIQ 6GWR 6HP9 6Y23 7BCM 7BE6
Enriched GO Terms of Interacting Partners?
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