TTK and USP16

Number of citations of the paper that reports this interaction (PubMedID 28380042)
5

Data Source:
BioGRID (enzymatic study)

		TTK	USP16
Description		TTK protein kinase	ubiquitin specific peptidase 16
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Cytoplasm Spindle Membrane	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Kinetochore Binding Protein Serine Kinase Activity	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Zinc Ion Binding Histone Binding Ubiquitin Binding
	Biological Process	Spindle Organization Mitotic Spindle Organization Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Positive Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Female Meiosis Chromosome Segregation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Meiotic Spindle Assembly Checkpoint Signaling Protein Localization To Kinetochore Protein Autophosphorylation Chromosome Separation Protein Localization To Meiotic Spindle Midzone	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Histone Deubiquitination Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Histone H2A K63-linked Deubiquitination Mitotic Nuclear Division
Pathways			Ub-specific processing proteases
Drugs		Pyrazolanthrone Fostamatinib BOS172722
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Macular thickness ( 30535121)
Interacting Genes		15 interacting genes: APP AZU1 CDCA8 CDK2 HSP90AA1 KNL1 MAPK6 NGEF POLR2A RAD52 RPS6KA1 TP53 TUBB TUBB1 USP16	23 interacting genes: ANAPC2 BTF3 CALM1 CCT8 CDK1 EXOSC10 FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4-16 LTN1 OR8G1 P2RX4 PLK1 PTOV1 SGIP1 SLC34A3 TTK UBC UBD
Entrez ID		7272	10600
HPRD ID		04973	06881
Ensembl ID		ENSG00000112742	ENSG00000156256
Uniprot IDs		P33981	Q9Y5T5
PDB IDs		2X9E 2ZMC 2ZMD 3CEK 3DBQ 3GFW 3H9F 3HMN 3HMO 3HMP 3VQU 3W1F 3WYX 3WYY 3WZJ 3WZK 4B94 4BHZ 4BI0 4BI1 4BI2 4C4E 4C4F 4C4G 4C4H 4C4I 4C4J 4CV8 4CV9 4CVA 4D2S 4H7X 4H7Y 4JS8 4JT3 4O6L 4ZEG 5AP0 5AP1 5AP2 5AP3 5AP4 5AP5 5AP6 5AP7 5EH0 5EHL 5EHO 5EHY 5EI2 5EI6 5EI8 5LJJ 5MRB 5N7V 5N84 5N87 5N93 5N9S 5NA0 5NAD 5NTT 5O91 6B4W 6GVJ 6H3K 6N6O 6TN9 6TNB 6TNC 6TND	2I50
Enriched GO Terms of Interacting Partners?
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