TTC1 and HSPA4

Number of citations of the paper that reports this interaction (PubMedID 14503850)
6

Data Source:
BioGRID (pull down, affinity chromatography technology)

		TTC1	HSPA4
Description		tetratricopeptide repeat domain 1	heat shock protein family A (Hsp70) member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisomal Membrane Cytosol	Nucleus Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Unfolded Protein Binding	Protein Binding ATP Binding
	Biological Process	Protein Folding	Response To Unfolded Protein Protein Insertion Into Mitochondrial Outer Membrane Chaperone-mediated Protein Complex Assembly
Pathways			Regulation of HSF1-mediated heat shock response
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS		Diastolic blood pressure ( 27841878) Hemoglobin levels ( 32327693) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)	Body shape index ( 34021172) Breast cancer ( 29059683) Chronic obstructive pulmonary disease ( 30804561) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eyebrow thickness ( 26926045) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 31928498) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Triglyceride levels ( 32203549 31928498 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		19 interacting genes: ACY1 CRY2 CYB5R1 GNA15 GNAI2 GNAQ GNAS HRAS HSPA1A HSPA4 HSPA8 NDE1 PSTPIP1 RNF41 SH3BP4 SOX5 SPP1 SREBF2 TGFBR1	69 interacting genes: ABCC2 AGTRAP AIMP2 APPBP2 BAG1 BAG2 BRMS1 CALM1 CD40 CDC73 CDKN2A CSNK1A1 CSNK2A1 DDIT4 DNAJB2 DUSP1 EGFR ESR1 FANCC FES FKBP4 GATA1 GRPEL2 GSK3B GZMA HAP1 HDAC3 HNRNPD HSPB1 HSPBP1 IKBKG KPNA2 KRT18 MUC1 NAA10 NEDD8 NFKB1 NR3C2 OLR1 PA2G4 PHLDA1 POU6F2 PPP1CA PRKACA PRKCB PRKCD PRKCG PRSS23 PSMD10 PTEN RAF1 RAP1A REL RELA SENP8 SGTA SIRPA SMAD3 ST13 STUB1 SUGT1 TERT TOMM40 TRAF6 TRIM32 TTC1 UBE2L3 UBE2M UBE3A
Entrez ID		7265	3308
HPRD ID		11881	09025
Ensembl ID		ENSG00000113312	ENSG00000170606
Uniprot IDs		Q99614	P34932
PDB IDs
Enriched GO Terms of Interacting Partners?
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