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TSC2 and LNX1
Number of citations of the paper that reports this interaction (PubMedID
22889411
)
17
Data Source:
BioGRID
(two hybrid)
TSC2
LNX1
Description
TSC complex subunit 2
ligand of numb-protein X 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Cytosol
Postsynaptic Density
Membrane
TSC1-TSC2 Complex
Perinuclear Region Of Cytoplasm
Cytoplasm
Molecular Function
GTPase Activator Activity
Protein Binding
Phosphatase Binding
Small GTPase Binding
Protein Homodimerization Activity
Hsp90 Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
PDZ Domain Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
Neural Tube Closure
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Endocytosis
Heart Development
Protein Localization
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Vesicle-mediated Transport
Positive Regulation Of Macroautophagy
Regulation Of Endocytosis
Negative Regulation Of Wnt Signaling Pathway
Negative Regulation Of TOR Signaling
Anoikis
Protein Kinase B Signaling
Positive Regulation Of GTPase Activity
Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Insulin Receptor Signaling Pathway
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Chemotaxis
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Cell Cycle
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Mitophagy
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Pathways
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
TBC/RABGAPs
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Major depressive disorder (
29317602
)
Obesity-related traits (
23251661
)
White blood cell count (
32888494
)
Beard thickness (
26926045
)
Cervical artery dissection (
25420145
)
DNA methylation (variation) (
23725790
)
Heel bone mineral density (
30598549
)
Height (
28552196
)
Peginterferon alfa-2a treatment response in chronic hepatitis B infection (
30972912
)
Uterine fibroids (
30194396
31649266
)
Interacting Genes
59 interacting genes:
ACTN2
AKT1
AKT2
AKT3
ANKRD35
CALM1
CBY2
CCND1
CDKN1B
EEF1A1
ESR1
FBXL6
FBXW5
GAPDH
GRB2
GSK3B
LNX1
MAPK1
MAPK3
MAPKAPK2
MDFI
MKRN1
MRPL21
NEK1
PAM
PHLDB1
PICK1
PIN1
PLK2
PPP2CA
PRKAA1
PTK2
PTPN11
RAB5A
RABEP1
RHEB
RPL4
RPS6KA1
RPSA
SEPTIN4
SERPINI1
SFN
SLC13A3
SMAD2
SMAD3
SSC4D
SUPT6H
TK1
TRIM55
TRIM63
TSC1
UBE3A
USPL1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
473 interacting genes:
ABCA1
ABCB1
ABI2
ABR
ACAT2
ACTN1
ACTN3
ACTN4
ACY3
ADAMTSL4
ADRA1D
AGTRAP
AIDA
AIMP2
AKIRIN2
ALDOC
ALKBH3
AMMECR1L
ANKS1A
AP1M1
APIP
APOL4
APP
ARF3
ARFIP2
ARHGAP6
ARHGEF16
ARVCF
ATPAF2
ATRIP
AURKB
AURKC
AXIN2
BCR
BEND7
BICD2
BIRC2
BLVRA
BLZF1
BORCS6
BPIFA1
BTBD1
C10orf88
C1QTNF1
CA8
CABP5
CADPS
CALCOCO2
CAMK2N2
CARD9
CASP6
CATSPERD
CBX1
CBY1
CBY2
CCBE1
CCDC102B
CCDC33
CCDC85B
CCDC88B
CCDC91
CCNDBP1
CDA
CDC42EP4
CDIPT
CDKN2D
CEP70
CEP72
CEP76
CEP85
CGN
CIB3
CIRBP
CITED1
CLDN1
CLDN17
CLDN2
CLK1
CLK2
CLK3
CMTM5
COIL
CPNE2
CPSF7
CRACR2B
CRX
CTBP1
CTNND2
CTSO
CUTC
CXADR
CYSLTR2
CYSRT1
DAB1
DAPK1
DCTD
DCTPP1
DCUN1D5
DDIT3
DDX17
DENND1B
DEPTOR
DERL1
DEUP1
DHPS
DMC1
DNPEP
DOCK9
DPF2
DRAP1
DRG1
DTX2
DUSP29
DVL3
DYDC1
DYNLT1
EBF4
EDC3
EEF2KMT
EFEMP2
EFHC2
EGLN3
EHMT2
EIF1AD
EIF4A3
EIF4H
ENOX1
ENOX2
EPHB3
EPM2AIP1
EVI5L
EXOC8
EXOSC1
EXOSC4
EXOSC8
FAM118A
FAM124A
FAM90A1
FAM9B
FASN
FBP1
FBXL12
FHL3
FOXP2
FSD2
FXR1
GAS2L2
GDI1
GIPR
GJD2
GJD4
GLRX3
GMCL1
GMNN
GOLPH3L
GPKOW
GPR142
GRAP2
GRB2
GRIN1
GRIPAP1
GUCD1
HDX
HEXIM2
HIP1
HMBOX1
HMG20A
HNRNPF
HNRNPH1
HOMER3
HOMEZ
HOOK2
HOXA1
HSBP1
HSF2BP
HTR2B
HUNK
IGSF5
IHO1
IKZF3
IL16
IL3RA
ILF3
INKA2
INO80E
INSC
IP6K3
ISCU
JAK3
JOSD1
KALRN
KATNAL2
KCNA4
KCTD1
KCTD13
KCTD17
KCTD6
KCTD7
KCTD9
KHDRBS2
KHDRBS3
KIAA1328
KIF24
KIFC3
KLHL12
KPRP
KRT15
KRT16
KRTAP1-1
KRTAP10-8
KRTAP12-3
KRTAP13-3
KRTAP2-3
KRTAP2-4
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
KXD1
LCLAT1
LCP2
LDB2
LDOC1
LEPROTL1
LGALS14
LGR6
LHX2
LNX2
LONRF1
LRRC3B
LRRC73
LSM2
LUZP4
LZTS1
MAD1L1
MAGEA11
MAGEB18
MAPK9
MAPRE2
MEMO1
MEOX2
METTL21A
MID2
MLX
MRFAP1L1
MRPS24
MRPS6
MSANTD4
MSC
MTMR9
MTUS2
MUSTN1
MVB12B
MYEF2
NAB2
NADK
NAGK
NBPF19
NCK2
NDC80
NDOR1
NDUFAB1
NECAB1
NECAB2
NEK6
NKD2
NME1
NME7
NOTCH2NLA
NRCAM
NUDT14
NUMB
NUP37
NUP62
NXT2
ODAD1
ORMDL1
ORMDL3
OSBP2
OSBPL3
OSGIN1
PAFAH1B3
PAICS
PAK5
PBK
PBLD
PCBD1
PDE3B
PDZRN3
PDZRN4
PFDN5
PKDREJ
PKM
PKP4
PLEKHA2
PNMA1
PNMA3
PNMA5
PNMT
POMGNT1
POU6F2
PPIA
PPID
PPIH
PPP1R13B
PQBP1
PRDM14
PRKAR1B
PRKRA
PRMT5
PRPH
PRR13
PRTFDC1
PSMC1
PSME2
PSME3
PSMF1
PTGIR
PTPN11
PTS
PURB
QARS1
RAB33A
RABAC1
RABIF
RAD51D
RAD54B
RALY
RASL11B
RBAK
RBCK1
RBM20
RBMX
RBMY1A1
RBMY1F
RBMY1J
REEP6
RFPL3
RGS20
RIOX2
ROBO3
ROPN1
RPIA
RPS6KA1
RUFY4
RUNDC3A
RUVBL2
S100A3
S100B
SAPCD1
SAT1
SCLT1
SCML1
SCML2
SCNM1
SDK1
SEPTIN1
SGF29
SH2D2A
SHFL
SHTN1
SLC6A15
SLC6A5
SNCB
SNRNP25
SNRPA
SNRPF
SOCS6
SP4
SPG21
SPHKAP
SRSF1
SRSF3
SSNA1
SSTR3
STAC2
STOML2
STRN
STX5
SUV39H1
SUV39H2
SYCE1L
SYTL2
TACO1
TAX1BP1
TBC1D1
TBCEL
TCF12
TCL1A
TDO2
TEKT4
TGM7
THAP1
THAP7
THG1L
TIFA
TMEM14C
TMEM239
TNFAIP1
TNFAIP3
TNFRSF18
TPM4
TRAF1
TRAF2
TRAF3
TRAF4
TRAF5
TRAF6
TRIM10
TRIM14
TRIM21
TRIM23
TRIM27
TRIM3
TRIM39
TRIM42
TRIM50
TRIM54
TRIM60
TRIM68
TRIM8
TRIP13
TRIP6
TRMT12
TSC2
TSC22D4
TSG101
TSN
TSPYL2
TSSK3
TYRO3
UBASH3A
UBE2D2
UBE2D4
UBP1
ULK2
UPP2
USP54
VASN
VCP
VMAC
VPS37B
VPS52
VRK2
WAC
WDR25
WNT8A
WWP1
YWHAZ
ZADH2
ZBED1
ZBTB2
ZBTB24
ZBTB26
ZBTB43
ZBTB8A
ZCCHC10
ZFP64
ZGPAT
ZNF148
ZNF213
ZNF263
ZNF346
ZNF426
ZNF446
ZNF552
ZNF581
ZNF593
ZNF655
ZRANB1
Entrez ID
7249
84708
HPRD ID
01850
17287
Ensembl ID
ENSG00000103197
ENSG00000072201
Uniprot IDs
B3KWH7
H3BMQ0
P49815
Q5HYF7
X5D7Q2
Q8TBB1
PDB IDs
7DL2
3B76
5H7R
5H7S
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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