TOP2A and SUMO2

Number of citations of the paper that reports this interaction (PubMedID 19394292)
81

Data Source:
BioGRID (pull down, pull down)

		TOP2A	SUMO2
Description		DNA topoisomerase II alpha	small ubiquitin like modifier 2
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Centriole DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex Protein-containing Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm PML Body
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding RNA Binding DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding Protein Binding ATP Binding Protein C-terminus Binding ATP-dependent Activity, Acting On DNA DNA Binding, Bending Enzyme Binding Protein Homodimerization Activity Histone Deacetylase Binding Ubiquitin Binding Protein Heterodimerization Activity	RNA Binding Protein Binding SUMO Transferase Activity Protein Tag Ubiquitin Protein Ligase Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Hematopoietic Progenitor Cell Differentiation DNA Topological Change DNA Ligation Cellular Response To DNA Damage Stimulus Chromosome Segregation Female Meiotic Nuclear Division Apoptotic Chromosome Condensation Embryonic Cleavage Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Negative Regulation Of DNA Duplex Unwinding	Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Transcription of E2F targets under negative control by DREAM complex SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins	Vitamin D (calciferol) metabolism SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER
Drugs		Moxifloxacin Amsacrine Dexrazoxane Valrubicin Teniposide Epirubicin Enoxacin Pefloxacin Ciprofloxacin Trovafloxacin Daunorubicin Etoposide Dactinomycin Lomefloxacin Doxorubicin Norfloxacin Ofloxacin Idarubicin Podofilox Mitoxantrone Sparfloxacin Genistein Fleroxacin Lucanthone Banoxantrone SP1049C Amonafide Elsamitrucin 13-deoxydoxorubicin RTA 744 Aldoxorubicin ZEN-012 Amrubicin Becatecarin Annamycin Declopramide Finafloxacin
Diseases
GWAS		Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Neutrophil percentage of white cells ( 32888494)	Deep white matter hyperintensities ( 32517579) Gamma glutamyl transferase levels ( 29403010 33339817) Serum metabolite levels ( 33031748) Type 2 diabetes ( 32499647)
Interacting Genes		30 interacting genes: BRCA1 CDK1 COPS5 CSNK2A1 DFFB DHX9 FBXO28 HDAC1 HDAC2 JUN MAPK1 MDM4 PIAS4 PIN1 PLK1 PRKCA PRKCB PRKCG RB1 RNF168 SMURF2 SRPK1 SUMO1 SUMO2 SUMO4 TOP2B TP53 UBE2I XPO1 YWHAE	454 interacting genes: AARS1 ABCF1 ABRAXAS1 ACIN1 ACTB AHCYL1 AHNAK AHNAK2 AIMP1 ALAS1 ANAPC1 ANAPC2 ANLN ANXA1 APRT ARF3 ARF4 ARID2 ASNS ASS1 ATF7IP ATRX ATXN7 BABAM2 BAD BAZ1A BAZ1B BLM BOD1L1 BPTF BRCC3 BZW1 C18orf25 CAD CALM1 CARS1 CAST CCAR2 CCNE2 CCT2 CCT3 CCT4 CCT5 CCT6A CDK2 CENPC CHAF1A CHAF1B CHAMP1 CHD3 CHD4 CHD8 CKAP5 CLTC CMTM6 COPA COPB2 COPG1 CPSF2 CPSF7 CSE1L CSNK2B CTNNBL1 CTNND1 CTR9 CUL3 CUX1 DAB2 DARS1 DAXX DCD DDX1 DDX17 DDX21 DDX39A DDX3X DDX5 DIDO1 DIP2B DNAJA1 DNM1L DNMT1 DYNC1H1 EDC4 EEF1A1 EEF1A2 EEF1G EEF2 EFTUD2 EGLN3 EHD4 EHMT1 EIF4A1 EIF4A2 EIF4G1 EIF4G2 EIF5A ELAC2 EME1 EMG1 EML3 ENO1 EP300 EP400 EPPK1 EPRS1 ERCC4 ERCC6 EXOSC10 EXOSC9 EZR FARSB FASN FBXO38 FLNA FLNB FOS GALK1 GAPVD1 GATAD2B GCN1 GEMIN5 GPATCH8 GTF2I GTF3C1 GTF3C2 GTF3C4 GYS1 HCFC1 HDAC1 HDAC2 HDAC4 HDAC9 HDLBP HIPK2 HK2 HMGXB4 HNRNPA0 HNRNPA1L2 HNRNPA2B1 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPLL HNRNPM HNRNPR HNRNPU HOMEZ HP1BP3 HPS6 HSF2 HSP90AA1 HSP90AB1 HSPA1A HSPA5 HSPA8 HSPA9 HSPB1 HSPD1 HUWE1 IARS1 ILK IMPDH2 INTS3 IPO5 IQGAP1 JUN KALRN KARS1 KDM1A KDM5C KIF11 KIF18B KIF23 KIF2A KIF2C KIF4A KIF5B KPNA2 KRT8 LARS1 LAS1L LEF1 LMNA LMO7 MAF1 MAP4 MARS1 MAST2 MCM3 MCM4 MDC1 MDN1 MKI67 MMS19 MORC3 MPI MRE11 MSH2 MSH3 MSH6 MSX1 MTA1 MTA2 MTHFD1 MUS81 MYB MYG1 NAP1L1 NARS1 NAT10 NBN NCAPD2 NCAPD3 NCAPG NCAPH2 NCL NCOR1 NFATC2IP NFE2L2 NIBAN2 NIPBL NOL9 NONO NOP2 NPM1 NSUN2 NUMA1 NUP107 NUP160 NUP214 ORC3 P4HA1 P4HB PAF1 PAK6 PALLD PARN PARP1 PBRM1 PDCD4 PDCD6IP PDS5A PELP1 PFKL PFKM PFKP PGK1 PHF3 PHF5A PHF8 PIAS1 PIAS2 PIAS3 PIAS4 PKM PKN2 PLEC PML POGZ POLA1 POLD1 POLR2A PPP1CC PPP2R1A PRC1 PRDX6 PRKDC PRPF6 PRPF8 PSMC1 PSMC3 PSMC4 PSMC5 PTBP1 RAD21 RAD50 RAD51 RAD54L2 RAN RANBP2 RANGAP1 RARS1 RBBP4 RBBP7 RCC1 RCOR1 RCOR2 RCOR3 RFC2 RFC4 RFC5 RIF1 RNF111 RNF168 RNF20 RNF213 RNF216 RNF4 RNF8 RPL10 RPL3 RPL4 RPS3 RPS4X RPS6KA3 RREB1 RRM1 RUVBL1 S100A10 SAE1 SAFB SAFB2 SAMHD1 SARS1 SART1 SCAF11 SENP1 SENP2 SENP3 SENP5 SENP6 SENP7 SERPINB6 SETDB1 SETX SF3A1 SF3B1 SF3B2 SIMC1 SIN3A SIRT1 SLC22A2 SLX4IP SMARCA4 SMARCAD1 SMC1A SMC2 SMC3 SMC4 SMCHD1 SND1 SNRNP200 SNW1 SNX27 SOBP SOX10 SOX6 SP1 SP100 SPATA5 SPATA5L1 SPR SPTAN1 SPTBN1 SRCAP SRP68 SRRM2 SRRT SSRP1 STAG2 STIP1 STRAP SUPT16H SUPT5H SYMPK SYNCRIP TAF1 TAGLN2 TCERG1 TCP1 TDG TDP2 TEAD3 TEX10 TK1 TLN1 TMPO TNIP1 TOP2A TOP2B TOPORS TP53BP1 TP53BP2 TPR TPX2 TRAF1 TRIM25 TRIM26 TRIM28 TRIM63 TRIML2 TRIP13 TRMT1L TSR1 TTI1 TTLL12 TUBA1B TUBA1C TUBA4A TUBB TUBB4A TUBB4B TUBB6 U2AF2 UBA1 UBA2 UBAP2L UBE2I UBR4 UIMC1 UMPS UPF1 USP11 USP25 USP28 USP48 USP5 USP7 USP9X USPL1 VARS1 VIM WAPL WASHC2C WDHD1 WRN XAB2 XPNPEP1 XPO1 XPO5 XRCC5 XRCC6 YWHAQ ZBED1 ZBTB2 ZBTB25 ZBTB33 ZBTB39 ZC3H11A ZCCHC12 ZCCHC7 ZHX1 ZMAT3 ZMYM2 ZMYM3 ZMYM4 ZMYM5 ZMYND8 ZNF451 ZNF496 ZNF638
Entrez ID		7153	6613
HPRD ID		00536	04332
Ensembl ID		ENSG00000131747	ENSG00000188612
Uniprot IDs		P11388	A0A024R8S3 P61956
PDB IDs		1LWZ 1ZXM 1ZXN 4FM9 4R1F 5GWK 5NNE	1WM2 1WM3 1WZ0 1Z5Q 2AWT 2CKH 2D07 2IO0 2IO3 2IYD 2N1W 2N9E 2RPQ 3UIN 3UIO 3ZO5 4BKG 4NPN 5D2M 5ELU 5EQL 5GHB 5GHC 6JXW 6JXX
Enriched GO Terms of Interacting Partners?
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