TNNC2 and TBC1D1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TNNC2	TBC1D1
Description		troponin C2, fast skeletal type	TBC1 domain family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Troponin Complex	Nucleus
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Calcium-dependent Protein Binding Actin Filament Binding	GTPase Activator Activity Protein Binding
	Biological Process	Skeletal Muscle Contraction Regulation Of Muscle Contraction	Intracellular Protein Transport Regulation Of Protein Localization Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Striated Muscle Contraction	Translocation of SLC2A4 (GLUT4) to the plasma membrane
Drugs		Felodipine Calcium Octylphenoxy polyethoxyethanol
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Bipolar disorder ( 34099189) Crohn's disease ( 23850713 23266558) Diastolic blood pressure ( 27841878 27618452) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) High-sensitivity cardiac troponin T levels ( 33321125) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: PIK3R3 TBC1D1 TNNI2 TNNI3	31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1
Entrez ID		7125	23216
HPRD ID		08929	18161
Ensembl ID		ENSG00000101470	ENSG00000065882
Uniprot IDs		C9J7T9 P02585	B9A6J6 Q6PJJ8 Q86TI0 Q8NC59
PDB IDs			3QYE
Enriched GO Terms of Interacting Partners?
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