TM7SF2 and CHRM4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		TM7SF2	CHRM4
Description		transmembrane 7 superfamily member 2	cholinergic receptor muscarinic 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Delta14-sterol Reductase Activity NADP Binding	G Protein-coupled Serotonin Receptor Activity G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity
	Biological Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Muscarinic acetylcholine receptors G alpha (i) signalling events
Drugs			Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
Diseases
GWAS		Blood protein levels ( 28240269)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		4 interacting genes: CHRM4 CYSRT1 LCE2C RAP2A	20 interacting genes: B2M CBFA2T3 CD59 CD81 EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 MFSD4A QSOX1 RAB3A RHBDD2 RTN4 SMIM7 SYN2 TM7SF2 TSPAN7 YIPF3
Entrez ID		7108	1132
HPRD ID		04564	00330
Ensembl ID		ENSG00000149809	ENSG00000180720
Uniprot IDs		A0A024R577 O76062	P08173
PDB IDs			5DSG 6D9H 6KP6
Enriched GO Terms of Interacting Partners?
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