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ACTG1 and LIG4
Number of citations of the paper that reports this interaction (PubMedID
22990118
)
49
Data Source:
BioGRID
(two hybrid)
ACTG1
LIG4
Description
actin gamma 1
DNA ligase 4
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Membrane
Myofibril
Filamentous Actin
Apical Junction Complex
Calyx Of Held
Phagocytic Vesicle
Extracellular Exosome
Blood Microparticle
Dense Body
Schaffer Collateral - CA1 Synapse
Basal Body Patch
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Cytoplasmic Ribonucleoprotein Granule
Nonhomologous End Joining Complex
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
Profilin Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Ligase Activity
Metal Ion Binding
Biological Process
Angiogenesis
Morphogenesis Of A Polarized Epithelium
Retina Homeostasis
Positive Regulation Of Gene Expression
Positive Regulation Of Cell Migration
Maintenance Of Blood-brain Barrier
Sarcomere Organization
Synaptic Vesicle Endocytosis
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Platelet Aggregation
Cellular Response To Interferon-gamma
Positive Regulation Of Wound Healing
Postsynaptic Actin Cytoskeleton Organization
Tight Junction Assembly
Regulation Of Transepithelial Transport
Protein Localization To Bicellular Tight Junction
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Replication
DNA Ligation
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Gamma Radiation
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
DNA Ligation Involved In DNA Recombination
DNA Ligation Involved In DNA Repair
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Chromosome Organization
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
Adherens junctions interactions
Adherens junctions interactions
Recycling pathway of L1
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF1 fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Clathrin-mediated endocytosis
RHOBTB2 GTPase cycle
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Sensory processing of sound by inner hair cells of the cochlea
Sensory processing of sound by outer hair cells of the cochlea
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
Drugs
Copper
Artenimol
Diseases
GWAS
Alanine aminotransferase levels (
33547301
33339817
)
Gamma glutamyl transferase levels (
33339817
)
Hand grip strength (
29313844
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Refractive error (
32231278
)
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Interacting Genes
69 interacting genes:
ABLIM1
ACTB
ANXA5
ATF7IP
BCAP31
BIN1
BRCA1
CAP1
CAP2
CAPZA3
CCDC22
CDC37
CDKN2A
CFL1
CFL2
COTL1
CTBP2
CTTN
CYBB
DISC1
DNASE1
DSTN
DUX4
DYNLL1
EHHADH
EIF6
FHOD1
FPR1
FXR1
GIT2
GSN
GZMA
GZMK
HRAS
HSPB2
LGALS13
LIG4
LINC01554
LSP1
MAP1A
MAPK6
MAPT
MCPH1
MYO1A
MYOC
NDRG1
NR3C2
NTAQ1
PFN2
PLD1
PLEC
PPP1R9A
PRSS23
PSEN2
PTPRO
RPS6KA5
SCIN
SH3GL2
SRPK2
ST3GAL3
SUMO4
TMSB4X
TMSB4Y
TNIK
VASP
VIL1
WASF1
WASL
WIPF1
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FAM214A
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
Entrez ID
71
3981
HPRD ID
00017
03500
Ensembl ID
ENSG00000184009
ENSG00000174405
Uniprot IDs
P63261
A0A024RE06
A0A0C4DGV9
A8K8Q4
P49917
PDB IDs
5JLH
6CXI
6CXJ
6G2T
6V62
6V63
6WK1
6WK2
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
7D9K
7D9Y
Enriched GO Terms of Interacting Partners
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