TLR3 and MAP2K6

Number of citations of the paper that reports this interaction (PubMedID 12609980)
95

Data Source:
BioGRID (enzymatic study)

		TLR3	MAP2K6
Description		toll like receptor 3	mitogen-activated protein kinase kinase 6
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Cytoplasm Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Extracellular Matrix Endolysosome Membrane	Nucleoplasm Cytosol Cytoskeleton
	Molecular Function	Double-stranded RNA Binding NAD+ Nucleosidase Activity Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatase Activator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Transcription Regulator Activator Activity
	Biological Process	Microglial Cell Activation Regulation Of Dendritic Cell Cytokine Production MyD88-independent Toll-like Receptor Signaling Pathway Inflammatory Response Hyperosmotic Response Signal Transduction Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation JNK Cascade Male Gonad Development Detection Of Virus Positive Regulation Of Gene Expression Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Type III Interferon Production Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Response To DsRNA Innate Immune Response Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Cellular Response To Mechanical Stimulus Cellular Response To Interferon-gamma Cellular Response To Exogenous DsRNA Cellular Response To Xenobiotic Stimulus Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of NIK/NF-kappaB Signaling	MAPK Cascade Osteoblast Differentiation Response To Ischemia Apoptotic Process DNA Damage Induced Protein Phosphorylation Signal Transduction Response To Xenobiotic Stimulus Regulation Of Gene Expression Peptidyl-tyrosine Phosphorylation Ovulation Cycle Process Positive Regulation Of Prostaglandin Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Stress-activated MAPK Cascade Regulation Of Cell Cycle Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cardiac Muscle Contraction Bone Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Cellular Response To Sorbitol Cellular Senescence Negative Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TLR3 deficiency - HSE UNC93B1 deficiency - HSE TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex	NOD1/2 Signaling Pathway Oxidative Stress Induced Senescence activated TAK1 mediates p38 MAPK activation Myogenesis PI5P Regulates TP53 Acetylation Interleukin-1 signaling
Drugs			Fostamatinib
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Breast size ( 22747683) Medication use (thyroid preparations) ( 31015401)	Body shape index ( 34021172) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Eye color ( 33692100) Optic disc size ( 31809533) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Response to TNF-alpha inhibitors in rheumatoid arthritis ( 22569225) Waist-hip ratio ( 28552196)
Interacting Genes		10 interacting genes: CD14 CHEK2 CSK HLA-DRA MAP2K6 MYD88 RNF216 TICAM1 TICAM2 TRAF6	39 interacting genes: AKT1 BECN1 BRAF CCND2 CDKN2B DCTN1 EPHA2 FBXO7 FGFR4 GLIS2 HGF HRAS LRRK2 MAP2K3 MAP2K4 MAP2K5 MAP3K20 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK12 MAPK13 MAPK14 MAPKAPK2 MLH1 NFE2L2 PICK1 PKN1 PLCB2 RAF1 RASSF1 RELA SMAD7 STAT4 STK11 TAOK2 TLR3 TRAF6
Entrez ID		7098	5608
HPRD ID		04324	03155
Ensembl ID		ENSG00000164342	ENSG00000108984
Uniprot IDs		O15455	A0A024R8K3 A8K3Y2 P52564
PDB IDs		1ZIW 2A0Z 2MK9 2MKA 3ULU 3ULV 5GS0 7C76	2Y8O 3ENM 3FME 3VN9 5ETF
Enriched GO Terms of Interacting Partners?
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