TLE3 and CSTF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TLE3	CSTF2
Description		TLE family member 3, transcriptional corepressor	cleavage stimulation factor subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex	Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Nuclear Body Cleavage Body
	Molecular Function	Transcription Corepressor Activity Protein Binding	RNA Binding MRNA Binding Protein Binding
	Biological Process	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis	MRNA Polyadenylation Pre-mRNA Cleavage Required For Polyadenylation Cellular Response To Nerve Growth Factor Stimulus
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression	tRNA processing in the nucleus mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 31562340) Hip circumference adjusted for BMI ( 34021172) L-selectin levels ( 25576479) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Monocyte percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 30046033 32439900) Pulmonary function ( 23932459) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Schizophrenia ( 25056061 29483656 30285260) Serum total protein level ( 29403010) Triglyceride levels ( 29403010 33339817) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 34021172 28448500) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: APP BIRC5 BMP3 CHERP CSTF2 FBXO7 FEM1B FOXG1 H2AC1 H3C1 H4C1 HINFP KRTAP15-1 NDRG1 NOTCH1 PIN1 RPL4 SIX1 SIX2 SIX3 SRP14 TAOK2 TCF7L2 XIAP	48 interacting genes: ABHD11 AKAP8L ANKRD10 APP ATP23 BAG6 CDSN CEACAM6 CEP126 CHD3 CNOT2 CSTF3 CTBP2 DDX1 ECH1 EEF1G ELP1 ERG28 FAM168B FEZ1 HDHD3 HGS IMMT INCA1 KAT5 METTL15 METTL27 MIR19A MIR92A2 POLR2A POU6F2 PPP1R32 PRDM6 RFX6 SPAG8 SS18L1 STH SUB1 SYMPK TFG TLE3 TLE5 TSC1 UBQLN1 UBQLN4 UFSP1 USP54 ZNF341
Entrez ID		7090	1478
HPRD ID		02558	02652
Ensembl ID		ENSG00000140332	ENSG00000101811
Uniprot IDs		B3KUA2 H0YL70 Q04726 Q6PRX3	B3V096 B4DUD5 E7EWR4 P33240
PDB IDs			1P1T 2J8P 6Q2I 6TZE
Enriched GO Terms of Interacting Partners?
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