THBS2 and RPS6KA2

		THBS2	RPS6KA2
Description		thrombospondin 2	ribosomal protein S6 kinase A2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Platelet Alpha Granule Collagen-containing Extracellular Matrix	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse Meiotic Spindle
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Heparin Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Negative Regulation Of Angiogenesis Positive Regulation Of Synapse Assembly	Oocyte Maturation Brain Renin-angiotensin System Signal Transduction Chemical Synaptic Transmission Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Meiotic Nuclear Division Heart Contraction Regulation Of Protein Processing Cellular Response To Carbohydrate Stimulus
Pathways		Signaling by PDGF Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS		Anorectal malformation ( 31136621) Blood protein levels ( 30072576 29875488) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Carotid intima media thickness x smoking interaction ( 32117412) Central corneal thickness ( 32528159 29760442) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Copper levels ( 26025379) Dimensional psychopathology (Cognitive) ( 29496196) Haemorrhoidal disease ( 33888516) Joint mobility (Beighton score) ( 27182965) Liver disease severity in Alagille syndrome ( 28090565) Obesity-related traits ( 23251661) Pulse pressure ( 28135244 27841878)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alzheimer's disease progression score ( 29860282) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood pressure (smoking interaction) ( 25189868) CafÃ©-au-lait macule number in neurofibromatosis type1 ( 32869517) Dental caries ( 23259602) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 27569725 23128233) Macrovascular complications in type 2 diabetes ( 33430853) Pre-treatment viral load in HIV-1 infection ( 31219150) Smooth-surface caries ( 24556642) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference ( 28552196)
Interacting Genes		4 interacting genes: MMP2 MMP9 RPS6KA2 THBS3	19 interacting genes: AFDN BAD CREB1 DYNLT1 DYNLT2 FLNC FOS JUN KCNJ6 L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 OTUD4 SHANK1 TBXT THBS2 TP53
Entrez ID		7058	6196
HPRD ID		01766	03403
Ensembl ID		ENSG00000186340	ENSG00000071242
Uniprot IDs		P35442	B7Z3B5 Q15349 X5D337
PDB IDs		1YO8 2RHP
Enriched GO Terms of Interacting Partners?
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