TGFA and ADAM17

  • Number of citations of the paper that reports this interaction (PubMedID 11823465)
  • 139
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vitro)

TGFA

ADAM17

Description transforming growth factor alpha ADAM metallopeptidase domain 17
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acne (severe) ( 24927181)
  • Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903)
  • Hair shape ( 29220522)
  • Hand grip strength ( 29691431 29313844)
  • Heel bone mineral density ( 30598549)
  • Hip minimal joint space width ( 27701424)
  • Longevity ( 20834067)
  • Low hand grip strength (60 years and older) (EWGSOP) ( 33510174)
  • Low hand grip strength (60 years and older) (FNIH) ( 33510174)
  • Neutrophil count ( 21507922)
  • Obesity-related traits ( 23251661)
  • Osteoarthritis ( 30664745)
  • Pulse pressure in young-onset hypertension ( 24892410)
  • Response to citalopram or escitalopram in depression ( 27622933)
  • Response to esketamine in treatment resistant depression ( 32724131)
  • Severe progression in rheumatoid arthritis ( 29065906)
  • Superior frontal gyrus grey matter volume ( 25335168)
Interacting Genes 17 interacting genes: ADAM10 ADAM17 EGFR ELANE ERBB2 ERBB4 GORASP1 GORASP2 LEPROTL1 MAGI2 MAGI3 NKD2 RHBDD1 RHBDF1 SDCBP SGTA SNTA1 15 interacting genes: DLG1 ERBB4 FHL2 MAD2L1 MAD2L2 NOTCH1 PTPN3 SH3D19 TGFA TIMP3 TNF TNFRSF1A TNFRSF1B TNFSF11 YIF1A
Entrez ID 7039 6868
HPRD ID 07522 04703
Ensembl ID ENSG00000163235 ENSG00000151694
Uniprot IDs E7EPT6 F8VNR3 P01135 B2RNB2 P78536
PDB IDs 1GK5 1MOX 1YUF 1YUG 2TGF 3E50 3TGF 4TGF 5KN5 1BKC 1ZXC 2A8H 2DDF 2FV5 2FV9 2I47 2M2F 2OI0 3B92 3CKI 3E8R 3EDZ 3EWJ 3G42 3KMC 3KME 3L0T 3L0V 3LE9 3LEA 3LGP 3O64
Enriched GO Terms of Interacting Partners?
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