TFRC and HFE

Number of citations of the paper that reports this interaction (PubMedID 9465039)
144

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		TFRC	HFE
Description		transferrin receptor	homeostatic iron regulator
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endosome Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle Extracellular Vesicle HFE-transferrin Receptor Complex	Extracellular Space Nucleoplasm Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Vesicle MHC Class I Protein Complex Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Terminal Web HFE-transferrin Receptor Complex
	Molecular Function	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Metalloexopeptidase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Co-receptor Binding Peptide Antigen Binding Transferrin Receptor Binding
	Biological Process	Regulation Of Cell Growth Positive Regulation Of Protein Phosphorylation Proteolysis Iron Ion Transport Cellular Iron Ion Homeostasis Positive Regulation Of Gene Expression Negative Regulation Of Mitochondrial Fusion Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Positive Regulation Of Peptidyl-serine Phosphorylation Transferrin Transport Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Bone Resorption Positive Regulation Of Isotype Switching Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Xenobiotic Stimulus Transport Across Blood-brain Barrier Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Negative Regulation Of T Cell Antigen Processing And Presentation Negative Regulation Of T Cell Cytokine Production Cellular Iron Ion Homeostasis Acute-phase Response Female Pregnancy Response To Iron Ion Cellular Response To Iron Ion Starvation Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Antigen Processing And Presentation BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Iron Ion Transport Hormone Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Iron Ion Homeostasis Multicellular Organismal Iron Ion Homeostasis Protein-containing Complex Assembly Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Liver Regeneration Iron Ion Import Across Plasma Membrane Negative Regulation Of Receptor Binding Positive Regulation Of Receptor Binding Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Ferrous Iron Binding Positive Regulation Of Transferrin Receptor Binding Response To Iron Ion Starvation Regulation Of Protein Localization To Cell Surface Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Signaling Receptor Activity Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle Transferrin endocytosis and recycling RND2 GTPase cycle RND1 GTPase cycle	Transferrin endocytosis and recycling
Drugs		Iron Ferrous sulfate anhydrous Ferric cation Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Tetraferric tricitrate decahydrate Ferric derisomaltose
Diseases
GWAS		Asthma ( 31959851 30929738) Asthma (adult onset) ( 30929738) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (total iron binding capacity) ( 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340) Mean corpuscular hemoglobin ( 32888494 28453575 20139978 27863252 19862010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 28453575 20139978 27863252 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 32499647)	Alanine aminotransferase levels ( 34315874) Alcohol consumption (transferrin glycosylation) ( 21665994) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 34315874) Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 21909110) Brain morphology (MOSTest) ( 32665545) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 24097068 20686565) Diastolic blood pressure ( 27841878 21909115 28739976 27618447 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling guilty ( 29500382) Fish- and plant-related diet ( 32066663) Glycated hemoglobin levels ( 34059833 20858683 28898252) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494 27863252 28017375 19862010) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 19820698 32888494 28453575 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) Hepcidin levels ( 21785125) Hepcidin/ferritin ratio ( 27846281) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Hip circumference adjusted for BMI ( 34021172) Hypertension ( 21909115) Intelligence (MTAG) ( 29326435) Iron status biomarkers ( 25224454 21483845 21149283 21208937 19820699 19084217) Iron status biomarkers (ferritin levels) ( 28334935 33536631 25352340) Iron status biomarkers (iron levels) ( 28334935 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935 33536631) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 33536631 25352340) LDL cholesterol ( 24097068 20686565) LDL cholesterol levels ( 32203549) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Liver iron content ( 34128465) Low density lipoprotein cholesterol levels ( 32154731) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 23263863 29403010 32888494 19853236 28453575 28017375) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252 28017375) Mean corpuscular volume ( 32888494 20139978 28017375 19862010) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Number of sexual partners ( 30643258) Osteoarthritis (hip) ( 30374069) Platelet count ( 32888494 27863252) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 23446634 20927387 23222517) Red cell distribution width ( 32888494 28957414) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Schizophrenia ( 30285260) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878 21909115 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		31 interacting genes: ACAP1 AQP6 ARL13B ASGR2 B4GALT1 C1orf159 CD247 CD4 CREB3L1 FAM209A FAM210B GABARAP GET1 GPR152 HFE HIBADH LHFPL5 LMNA MFF MGST3 PAGE1 RAB5B RAB8A RANBP9 RASSF3 RELL2 RMDN3 SGTA SLC10A1 SLC18A1 TF	3 interacting genes: B2M TFR2 TFRC
Entrez ID		7037	3077
HPRD ID		01812	01993
Ensembl ID		ENSG00000072274	ENSG00000010704
Uniprot IDs		A8K6Q8 B7Z2I6 G3V0E5 P02786 Q7Z3E0	B4DV50 F8W7W8 Q30201
PDB IDs		1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I 6OKD 6W3H 6Y76	1A6Z 1C42 1DE4
Enriched GO Terms of Interacting Partners?
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