TFAP4 and EXOSC8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		TFAP4	EXOSC8
Description		transcription factor AP-4	exosome component 8
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Transcription Repressor Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Protein-containing Complex Assembly Cellular Response To Dexamethasone Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Biological_process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Exonucleolytic Catabolism Of Deadenylated MRNA Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways			ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lung function (FEV1/FVC) ( 26635082) Platelet count ( 32888494) Prostate-specific antigen levels ( 28139693) Serum alkaline phosphatase levels ( 33547301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		12 interacting genes: AJUBA EXOSC8 GOLGA2 INCA1 MCRS1 PDE9A PTPN3 SFMBT2 TEKT4 TRAF1 TRAF4 VMAC	79 interacting genes: AEN ATF2 C22orf39 CAB39L CCDC28A-AS1 CNNM3 COL23A1 COX5A CRMP1 CWC22 DDIT4L DIS3 DUSP23 EEF1DP3 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 GEM HAPLN2 HOXB9 INCA1 KANK2 KCNJ11 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR MAPK8IP1 MKRN1 MORN4 MPHOSPH6 MTREX MYOZ1 N4BP2L2 NEDD9 NTAQ1 OTUD4 PALS2 PDCD1LG2 PHF21A PIAS2 POLDIP3 RASD1 RASSF1 REL RERG RFC5 RPP14 RUSC1 RXRB SLAIN1 SNAI1 SNRPB SNRPC SOCS7 SPATC1L TCEA2 TFAP4 TXNDC17 TXNDC9 UBC UPF2 USP2 USP6 XRN1 XRN2 ZFP36
Entrez ID		7023	11340
HPRD ID		11795	09351
Ensembl ID		ENSG00000090447	ENSG00000120699
Uniprot IDs		Q01664	Q96B26
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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